Solution Engineer - Diagnostics

Roche • Pleasanton, CA

48d

About The Position

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. We are seeking a highly motivated Principal System Engineer I to join our End-to-End Solution Integration Chapter supporting Next-Generation Diagnostic Solutions. In this hands-on role, you will drive feasibility, development, and integration of complex multi-disciplinary systems spanning sample preparation, library preparation, molecular detection technologies (e.g., digital PCR, sequencing by synthesis, microarray), and bioinformatics/data processing pipelines. The Opportunity: This role is ideal for a systems-minded engineer with direct industry experience in sequencing workflows, strong analytical and statistical skills, and the ability to influence cross-functional projects without formal people management responsibilities. Who You Are: You will collaborate with assay, software, hardware, and bioinformatics teams to define, integrate, and optimize system-level performance, ensuring technical robustness and operational scalability across diverse technologies.

Requirements

• systems-minded engineer
• direct industry experience in sequencing workflows
• strong analytical and statistical skills
• ability to influence cross-functional projects without formal people management responsibilities

Responsibilities

• Drive end-to-end system development and integration across wet lab workflows, instruments, and data pipelines for next-generation diagnostic solutions.
• Perform hands-on system integration and troubleshooting of complex workflows, including molecular detection technologies and data transfer.
• Partner with assay, software, and bioinformatics teams to ensure seamless integration of sequencing output with downstream analysis pipelines.
• Apply advanced statistical analysis and Design of Experiments (DoE) methodologies (e.g., Python, JMP) to characterize, optimize, and set subsystem specifications.
• Plan, design, and execute comprehensive Verification and Validation (V&V) test cases to ensure complete requirements coverage.
• Support post-launch troubleshooting and field investigations through failure mode and root cause analyses.
• Represent Systems Engineering in cross-functional project teams and contribute to essential system documentation and continuous workflow improvement.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: No Education Listed
• Number of Employees: 5,001-10,000 employees