Small-Scale Purification Scientist
About The Position
About the Role The Small-Scale Purification Scientist is a hands-on technical contributor in the Bioprocess Design Center (BDC), responsible for designing, executing, and documenting downstream purification experiments that generate high-quality technical evidence for Thermo Fisher Scientific’s single-use purification technologies. This role operates at the intersection of experimental execution and systems-level process understanding. The successful candidate will independently own small-scale downstream studies, translate experimental outcomes into actionable insights, and support integrated end-to-end workflow development across upstream, harvest, and downstream unit operations. Familiarity with Thermo Fisher Scientific’s single-use downstream purification equipment, consumables, and workflow architectures is highly valued and will enable rapid execution within BDC laboratory and customer-facing environments.
Requirements
- B.S. in Chemical Engineering, Biochemistry, Biotechnology, Bioengineering, or related field with 3–5 years of relevant downstream experience
- M.S. with 2–3 years of relevant experience
- Equivalent combinations of education and experience will be considered
- Hands-on experience with downstream purification and bioprocessing workflows
- Familiarity with selection, setup, and operation of single-use chromatography columns, flow kits, and UF/DF systems.
- Experience designing and executing controlled experiments; DoE experience preferred
- Strong data analysis, documentation, and technical writing skills
- Proficiency with standard data analysis and reporting tools (e.g., Excel, PowerPoint)
Nice To Haves
- Demonstrated ability to work independently in a fast-paced, matrixed environment
- Strong problem-solving skills and attention to detail
- Ability to translate experimental data into practical, workflow-relevant insights
- Comfort operating in environments with evolving priorities and requirements
- Collaborative, customer-centric mindset
Responsibilities
- Experimental Design & Execution Execute purification resin design studies for internal and external customers using Thermo Fishers brand resins.
- Independently design and execute small-scale downstream purification experiments spanning capture, intermediate, and polishing operations.
- Develop experimental plans aligned to defined technical objectives, including appropriate controls, success criteria, and data quality expectations.
- Execute chromatography and filtration processes (e.g., column screening, process optimization, UF/DF) with a focus on Thermo Fisher single-use chromatography and centrifugation systems.
- Troubleshoot experimental issues and drive resolution with minimal supervision.
- Systems & Workflow Awareness Apply systems-level thinking to understand how downstream purification integrates with upstream processes, automation, analytics, and overall workflow design.
- Support evaluation of single-use purification technologies, process configurations, and operating strategies.
- Identify operational risks, constraints, and improvement opportunities during experimental execution.
- Data Analysis & Documentation Analyze experimental data, identify trends, and draw scientifically defensible conclusions.
- Author protocols, technical reports, summaries, and SOPs suitable for internal use and customer-facing communication.
- Maintain complete, accurate laboratory notebooks and records in accordance with internal data integrity and IP standards.
- Collaboration & Communication Support customer visits, technical demonstrations, and internal reviews by clearly articulating experimental intent, methods, and results.
- Communicate progress, risks, and outcomes effectively to both technical and non-technical stakeholders.
- Laboratory Operations & Compliance Maintain a safe, compliant, and well-organized laboratory environment.
- Follow applicable safety, quality, and training requirements (e.g., GLP, ISO, internal EHS standards).
- Contribute to continuous improvement of downstream laboratory workflows and experimental practices.
- Support preparation of bills of materials and logistical needs for BDC projects and customer activities.
Benefits
- A choice of national medical and dental plans, and a national vision plan, including health incentive programs
- Employee assistance and family support programs, including commuter benefits and tuition reimbursement
- At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
- Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
- Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
