Senior/Staff Scientist, Surface Chemistry
About The Position
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you We are seeking a highly skilled and experienced Surface Chemist who will be responsible for developing solid-phase supports for DNA synthesis and protein sequencing via Glyphic’s proprietary technology. This role reports to the Director of Chemistry and requires expertise in surface chemistry, solid-phase synthesis, and analytical techniques. The successful candidate will work independently in a laboratory environment and collaborate effectively with cross-functional teams. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.
Requirements
- Degree in organic chemistry, surface chemistry, bioengineering or equivalent field. Advanced degree preferred.
- 6+ years (PhD), 8+ years (MS), 10+ years (B.S.) of industry or equivalent experience in assay or reagent development.
- Demonstrated proficiency in surface and morphological characterization (AFM, SEM/TEM, XPS, contact angle, DLS, zeta potential).
- Expertise in surface and solid-phase chemistry, including surface modification, functional group coupling (and quantitation), and polymer or nanoparticle surface engineering.
- Demonstrated proficiency in analytical characterization, including LC–MS, HPLC, FTIR, UV–Vis, fluorescence spectroscopy, and elemental analysis.
- Hands-on experience with bioconjugation chemistry, such as coupling of proteins, peptides, small molecules, or oligonucleotides via covalent or affinity-based linkers.
- Excellent problem-solving skills and attention to detail.
- Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
- Ability to thrive in a fast-paced environment with evolving priorities.
Nice To Haves
- Familiarity with microfluidics and flow cells.
- Experience in photochemistry and photocatalysis.
- Experience with automation platforms for liquid handling (e.g. Hamilton, ThermoFisher, Agilent).
- Familiarity with statistical methods or computational tools for process/data analysis.
- Experience supporting technology transfer into production environments.
Responsibilities
- Develop solid supports that meet the physicochemical performance requirements for a novel single molecule protein sequencing workflow and will be compatible with automation equipment.
- Source and synthesize custom supports to investigate surface functionalization, porosity, size, stability, and manufacturability.
- Optimize functionalization chemistries (includes covalent, cleavable, linkers, passivation) to improve interfacial reaction kinetics and efficiency and assay signal-to-noise.
- Develop and validate analytical methods to characterize/QC solid supports.
- Develop and validate functional testing methods to characterize/QC solid supports.
- Partner with scientists and engineers to deploy novel supports into SOP workflows.
- Design and execute experiments bridging chemistry and molecular biology.
- Analyze experimental data, generate detailed reports, and provide actionable insights to guide further development.
- Apply statistical methods and process evaluation tools to ensure workflow quality and performance.
- Prepare and maintain comprehensive documentation of protocols, SOPs, and results.
- Contribute to process innovation and support technology transfer as workflows mature.
Benefits
- Employee Stock Option Plan
- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
- Employer Retirement Contributions to 401(k)
- Generous Paid Time Off
- Paid Maternity and Paternity Leave
- Health & Wellbeing Program
- Office Snacks and Beverages
- Regular Team Bonding Activities
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Number of Employees
11-50 employees
