Senior/Staff Scientist, Biopolymer Chemistry
About The Position
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. Glyphic is seeking a highly motivated and experienced Scientist to join the Chemistry Department to assist in the advancement of our cutting-edge single molecule proteome sequencing platform. The ideal candidate will have a strong background in peptide chemistry, bioconjugation, analytical instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross-disciplinary team of scientists, engineers, and bio-informaticians to rapidly deliver consistent results and insights that accelerate the development cycle.
Requirements
- Degree in chemistry, organic chemistry, or related field. Advanced degree preferred.
- 4+ years (PhD), 6+ years (MS), 8+ years (B.S.) of industry or equivalent experience in peptide chemistry
- Hands-on development, optimization, and troubleshooting of solid-phase peptide synthesis (SPPS) protocols.
- Experience developing methods for one or more of the following: advanced orthogonal protecting group strategies (beyond Fmoc/Boc); site-specific amino acid chemistry; segment coupling methods akin to native chemical ligation and C-terminal thioester intermediates; and/or selective on-resin modification of aromatic sidechains (Trp, Tyr) for fluorophore labeling.
- Proven experience with bioconjugation and biorthogonal conjugation methods
- Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE
- Experience in data analysis software
- Experience in statistical and DOE software
- Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
- High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
- Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
- Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences.
Nice To Haves
- C-terminal conjugation, and modification of amino acid sidechains beyond cysteine and lysine.
- Experience with nucleic acid synthesis, natural and modified analogs
- Knowledgeable about protein purification and fractionation from complex sample matrices
- Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports
- Experience in an industrial or startup setting
- Experience in the development of commercial products
Responsibilities
- Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility
- Synthesize assay specific reagents and materials for the proteome sequencing platform
- Develop and/or validate peptide sample preparation schemes, such as C-terminal conjugation and amino acid sidechain derivatization
- Collaborate with cross-functional teams to problem solve and integrate novel solutions into the assay workflow
- Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development
- Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control
- Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results
- Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development
Benefits
- Employee Stock Option Plan
- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
- Employer Retirement Contributions to 401(k)
- Generous Paid Time Off
- Paid Maternity and Paternity Leave
- Health & Wellbeing Program
- Office Snacks and Beverages
- Regular Team Bonding Activities
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Number of Employees
11-50 employees
