Senior Specialist, Quantitative Pharmacology and Pharmacometrics - Infectious Disease and Vaccines

MSD

93d • $126,500 - $199,100

About The Position

Senior Specialists in the Infectious Disease and Vaccines group in the department of Quantitative Pharmacology and Pharmacometrics (QP2) apply quantitative approaches to enable drug-development decision-making from drug discovery through approval. Senior Specialists will work in collaborative teams and with more experienced scientists across disciplines, and are expected to have or develop expertise in one or more areas necessary to perform the primary responsibilities of the role including: Applying quantitative approaches to develop and implement translational clinical pharmacokinetics and pharmacodynamics of new drug and vaccine candidates. Developing and executing pharmacokinetics and pharmacodynamics modelling approaches, such as noncompartmental analysis, population pharmacokinetic, exposure-response, quantitative system pharmacology, viral dynamics, model-based meta-analysis, and other model-based analyses. Perform clinical trial simulations to inform dose selection and go/no-go decisions. Serve as a QP2 representative while being mentored by QP2 senior staff on drug and vaccine development teams to manage functional deliverables for assigned programs. On the job, you will begin to develop a comprehensive understanding of global regulatory expectations of drug and vaccine development, including clinical trial design, clinical pharmacology, biomarker plans, and model-based drug development approaches. You will also develop leadership skills in areas such as mentoring, managing a program, project, or initiative. Collaboration within the group and with other functional areas, as well as with external vendors and partners, to create an aligned, quantitative framework to impact decisions of drug development teams is also crucial. The ideal candidate is collaborative and eager to learn. Excellent communication skills both written and verbal are required, including the ability to clearly present scientific data in cross functional group settings. QP2 offers a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies.

Requirements

• A Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least two years of experience - OR- a MS or equivalent degree with at least four years of experience.
• An educational background in PK/PD, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
• Proficiency in R, NONMEM, Matlab, Python, or a similar programming language.
• Proficiency in written and verbal communication.

Nice To Haves

• Knowledge of infectious diseases.
• Experience performing population PK and/or PK/PD analyses.
• Experience with standard pharmacometrics software (e.g. NONMEM, Monolix, Phoenix).
• Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
• Scientific understanding of ADME and biopharmaceutic properties of biologics, small molecules, or non-traditional therapeutics.

Responsibilities

• Apply quantitative approaches to develop and implement translational clinical pharmacokinetics and pharmacodynamics of new drug and vaccine candidates.
• Develop and execute pharmacokinetics and pharmacodynamics modelling approaches, such as noncompartmental analysis, population pharmacokinetic, exposure-response, quantitative system pharmacology, viral dynamics, model-based meta-analysis, and other model-based analyses.
• Perform clinical trial simulations to inform dose selection and go/no-go decisions.
• Serve as a QP2 representative while being mentored by QP2 senior staff on drug and vaccine development teams to manage functional deliverables for assigned programs.
• Develop a comprehensive understanding of global regulatory expectations of drug and vaccine development, including clinical trial design, clinical pharmacology, biomarker plans, and model-based drug development approaches.
• Develop leadership skills in areas such as mentoring, managing a program, project, or initiative.
• Collaborate within the group and with other functional areas, as well as with external vendors and partners, to create an aligned, quantitative framework to impact decisions of drug development teams.

Benefits

• Medical, dental, vision healthcare and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees