Mayo Clinic Genomics and Emerging Systems Unit is seeking a Sr. Software Engineer to design, develop, and maintain robust .NET-based back-end services supporting a broad portfolio of genomics and clinical applications. These systems operate across on-premises environments and modern cloud platforms, including Azure and Google Cloud Platform (GCP), and integrate with distributed services through secure APIs and web services. The Software Engineer will build and optimize services that handle complex genomic workflows, large-scale clinical datasets, and high-throughput data processing. This includes ensuring that all services meet strict performance, reliability, and accuracy requirements, scale effectively as data volumes grow, and remain resilient within hybrid cloud ecosystems. The role collaborates closely with Product Owners, Product Managers, Architects, and cross-functional engineering partners to translate requirements into well-architected, maintainable code. Responsibilities include designing and implementing services aligned to enterprise architecture, including cloud-ready APIs, data integration pipelines, and secure interoperability layers for genomic systems. The engineer participates in Agile and DevOps practices using GitHub, Azure DevOps (ADO), Azure Pipelines, and CI/CD frameworks. Work may include deployment automation and configuration management using tools such as ARM/Bicep, Terraform, Cloud Build, or Azure Pipelines, supporting both on-prem and cloud-hosted applications. Development efforts leverage modern .NET technologies, cloud-native patterns, API-first design, and secure coding practices. Responsibilities also include maintaining comprehensive technical documentation, contributing to code reviews, and participating in expert-level troubleshooting through log analysis, root cause evaluation, and data/system investigation. This position requires effective communication with peers, leaders, and clinical partners across the organization. The engineer will continue to build knowledge of genomics workflows, organizational processes, and customer needs while performing a range of technical assignments with moderate guidance and increasing autonomy. Designs and builds back-end services that support our portfolio of data-centric clinical and analytic applications. These applications leverage cloud computing, big data, mobile, data science, data warehousing, machine learning using state of the art software development applications and frameworks. Our Software Engineers ensures that these cloud-based micro-services adhere to uptime and accuracy targets, are resilient, and scale as data volumes and traffic increase. They work closely with the data engineering, platform, and solutions teams to develop applications as required to benefit our practice and patients. Works closely with the Product Owners, Product Managers, Architects to translate requirements into code. Developing services around data warehousing, big data, cloud computing, business intelligence, analytics and machine learning. Participate in DevOps, Agile, continuous development and integration frameworks. Programming in high-level languages such as Go, Python, Java etc. Ensure all appropriate documentation of processes and source code is created and maintained. Communicate effectively with peers, leaders, and customers throughout the organization. Participate in expert level troubleshooting and resolve problems through root cause analysis, data and system investigation. Contributes to design and architecture discussions with Principals and Architects. Leads targeted cross-functional improvement efforts and mentors more junior software engineers. Solves complex problems; takes a new perspective on existing solutions. Work independently with minimal guidance. You may lead projects or project steps within a broader project or have accountability for ongoing activities or objectives. Act as a resource for colleagues with less experience. This is a full time, remote position within the United States. Mayo Clinic will not sponsor or transfer visas for this position including F1 OPT STEM.