Senior Scientist

Summit Therapeutics Sub • Palo Alto, CA

1d • $135,000 - $160,000

About The Position

About Summit: Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summits core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence. Summits team is inspired to touch and help change lives through Summits clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including: Non-small Cell Lung Cancer (NSCLC) HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI. HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC. HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC. Colorectal Cancer (CRC) HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy. Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than Chinas National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland. Overview of Role: The Senior Scientist will take primary ownership of laboratory activities. It is a highly hands-on position to drive the research of the mechanism of action (MOA) of ivonescimab and related bispecific antibodies, and to play an integral role in the discovery and development of pipeline molecules.

Requirements

• PhD with 3+ years or MS with 5+ years industry experience in Immunology, Cancer Biology, Molecular/Cellular Biology, or related fields.
• Demonstrated expertise and a strong publication record in immuno-oncology and/or angiogenesis biology fields.
• Strong technical skills in the design, execution and data analysis using wild type or genetically engineered syngeneic tumor model in mice, as well as xenogeneic/PDX tumor model in mice; using organoid systems and primary human leukocytes.
• Technical proficiency in design, execution and data analysis using 10+ colors flow cytometry analyzers and sorters is a must-have qualification.
• Strong record of scientific communication (presentations, posters/manuscripts) and cross-functional collaboration.

Nice To Haves

• Candidates with additional expertise in multiplex IHC or fluorescent microscopy, single-cell RNAseq, or spatial transcriptomic technology platforms will be highly desirable.
• Candidates with additional skillsets in antibody screening, such as affinity measurement and reporter gene assays for target binding or blockade will also be highly preferable.

Responsibilities

• MOA Research : Design and execute in vitro and in vivo studies, work with CROs and academic labs to elucidate the mechanism at the molecular, cellular and tumor-immune system levels.
• Translate the findings into a deeper understanding of therapeutic efficacy and resistance biology in different cancer indications that can guide indication expansion, rational drug combinations, and biomarker development.
• Pipeline Development : Design and execute experiments to create, characterize and advance the development of candidate molecules.
• Contribution to cross-functional governance: Produce in-depth analyses as well as executive summaries to inform internal stakeholders.
• Serve as the subject matter expert in cross-functional teams to facilitate decision-making.
• Author conference abstracts and presentations, submit manuscripts to peer-reviewed journals to share findings with the scientific and medical communities.
• Contribution to competitive intelligence collection: Evaluate emerging technologies, literature, and competitive landscapes to inform innovation and pipeline development.
• All other duties as assigned, including the maintenance of Summit research facilities.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree