Senior Scientist

Sanofi•Framingham, MA

About The Position

We seek a highly motivated candidate to join Cell Line Development (CLD), responsible for generating mammalian cell lines for Sanofi's R&D biologics pipeline and implementing new technologies and processes for continuous platform improvement. CLD, located in Framingham MA, is a global function, supporting research and early development projects at three Sanofi R&D Hubs (North America, France, Germany), and team members routinely work with colleagues at different sites. The person in this role will work in a high-performing, fast-paced collaborative environment, ensure project goals and timelines are met, and help drive optimization for cell line production of biologics including antibodies and diverse, novel formats. Work will directly support development projects within Sanofi's pipeline. The position also provides the opportunity to work on global teams, contribute to operational excellence and other transversal initiatives, and have a direct impact on shaping our future cell line expression platforms. Join the engine of Sanofi's mission — where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions. We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives.

Requirements

PhD (plus 1-2 yr experience) in Biology, Cell Biology, Molecular Biology, Bioengineering, or related discipline, or Master's degree in relevant discipline with Minimum >4yr of relevant experience.
Hands-on experience in mammalian cell line development in a pharmaceutical or biotechnology setting.
Experience using automation platforms is highly desirable (Beckman, Tecan, Hamilton, Beacon, VIPS, etc.)
Strong technical background and attention to detail.
Self-motivated with excellent communication, organization and time-management skills.
Demonstrated ability to work independently and in a highly collaborative environment and adhere to timelines.

Nice To Haves

Suspension mammalian cell culture experience (CHO cell culture) in a pharmaceutical or biotechnology setting.
Experience in mammalian gene expression systems, gene editing and/or 'omics technologies, gene expression optimization.
Experience and working knowledge in high-throughput screening tools (bioreactors, analytics) for cell line selection.
Flexibility and a willingness to expand skill set and responsibilities, and excel in a past-faced highly cooperative team environment, ability to multitask, adaptability and positive attitude.
Experience with genetic characterization methods such as ddPCR, qPCR, gel electrophoresis, and DNA sequencing analysis.
Experience with molecular cloning techniques including Gibson assembly, Golden Gate cloning, restriction cloning, and PCR-based methods.
Demonstrated expertise in DNA construct design, vector engineering, and plasmid preparation.

Responsibilities

Technical oversight and delivery of end-to-end cell line development work packages (as CLD Lead & Operator) to meet deliverables for preclinical and clinical development projects, including reports and presentations to stakeholders.
Perform cell culture techniques for both pool and clone generation of expressive populations.
Actively engage and contribute to optimize cell line generation process towards using an automation-enabled high-throughput cell line platform.
Represent the CLD function on project teams and within Global CMC, making decisions for cell line activities and effectively communicating results, progress and plans.
Active engagement and collaboration with global DS teams as the CLD representative.
Drive innovation strategies for generating cell lines, to ensure "right first time" delivery of commercial-ready cell lines.
Active engagement with Research functions ensuring smooth transition of projects and data.
Compliance with all applicable regulations, ensure that work performed is conducted in a safe and compliant manner, ensure maintenance of proper records in accordance with SOPs and policies.
Prepare and review documentation for regulatory submissions.

Benefits

Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
Help improve the lives of millions of people globally by making drug development quicker and more effective.
Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

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