Senior Scientist

AstraZeneca•Gaithersburg, MD

12d•Onsite

About The Position

Senior Scientist Introduction to role We are seeking a highly motivated Senior Scientist with extensive expertise in cancer immunology/immunotherapy. The successful candidate will have substantial experience in studying T cells and myeloid cells both in vivo and in vitro, with a specific interest in myeloid cell progenitors and/or lipid metabolism. You will independently design and execute projects/experiments, troubleshoot and optimize methods, and generate, interpret, and report scientific data clearly and concisely. A PhD in Immunology or a related field and a proven postdoctoral record with strong publications are required. Strong expertise with mouse tumor models is desirable. This is an onsite role requiring 5 days per week of onsite presence. As a Senior Scientist in our Oncology R&D department, you will be a key member of a team focused on designing novel therapeutics to target myeloid biology and immunotherapy, supporting projects through the drug discovery and development process. You will bring your theoretical and practical expertise in immunology to establish assay systems and deliver datasets that will have a direct impact on immune-oncology therapeutics.

Requirements

A PhD in immunology, cancer biology, or related field with minimum of 2 years of experience
Extensive experience in studying T cells or myeloid cells: MDSC, macrophages, dendritic cells, expertise or knowledge of peptide vaccines
Strong hands-on skills in basic biochemical and immunological methods including multi-color flow cytometry (FACS), ELISA/multiplex assays, western blotting, luminescence assays, cell killing assays, high content imaging
Excellent organizational and communication skills
Ability to work in a high-paced team environment, plan and meet timelines
Proven track record of success in your research, and experience preparing written scientific reports (e.g., manuscripts) and oral presentations to broad and diverse audiences

Nice To Haves

In vivo expertise in murine tumor models
Experience developing cancer immunotherapy including cancer vaccines and cellular therapies

Responsibilities

Independently conduct mechanistic cancer immunology and drug discovery research experiments using techniques in immunology, molecular, and cellular biology
Assess and report data with little guidance in a clear and concise manner with a strong understanding of its implications within the overall context of drug discovery
Maintain a well-developed understanding of approaches to investigate the function of myeloid cells and aspects of drug discovery
Actively liaise between programs/departments, sharing scientific knowledge and feedback on others’ experiments to ensure efficient relay of information and translation of data
Ensure own work and work of peers is compliant with Good Laboratory Practice, Safety, Health, and Environment standards, and all other relevant internal AstraZeneca standards and external regulations
May be asked to lead or co-lead a project team and contribute to scientific publication goals