Amgen-posted 2 months ago
$130,278 - $151,932/Yr
Full-time • Senior
Hybrid • Thousand Oaks, CA
5,001-10,000 employees
Chemical Manufacturing

Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

  • Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
  • Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
  • Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
  • Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
  • Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
  • Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
  • Share insights through internal presentations, publications, and external conferences.
  • Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.
  • Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master's degree and 3 years of directly related experience OR Bachelor's degree and 5 years of directly related experience.
  • PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
  • 2+ years of relevant industry experience (biotechnology or pharmaceutical research).
  • Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
  • Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
  • Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
  • Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
  • Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
  • Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
  • Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
  • Stock-based long-term incentives.
  • Award-winning time-off plans.
  • Flexible work models, including remote and hybrid work arrangements, where possible.
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