Amgen-posted 3 months ago
$130,278 - $151,932/Yr
Full-time • Senior
Thousand Oaks, CA
5,001-10,000 employees

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

  • Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
  • Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
  • Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
  • Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
  • Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
  • Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
  • Share insights through internal presentations, publications, and external conferences.
  • Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.
  • Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
  • Master’s degree and 3 years of directly related experience
  • Bachelor’s degree and 5 years of directly related experience
  • PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
  • 2+ years of relevant industry experience (biotechnology or pharmaceutical research).
  • Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
  • Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
  • Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
  • Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
  • Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
  • Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
  • Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
  • Stock-based long-term incentives.
  • Award-winning time-off plans.
  • Flexible work models, including remote and hybrid work arrangements, where possible.
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