Senior Scientist Target Discovery and Biology

Amgen•South San Francisco, CA

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist – Target Discovery and Biology What you will do Let’s do this. Let’s change the world. In this vital role you will join an enthusiastic, fast-paced team utilizing cutting-edge omics and cellular profiling technologies to advance target discovery, validation, and progression across Amgen’s therapeutic areas. Conduct impactful high throughput screening and profiling approaches for target discovery Help identify and implement new technologies to accelerate discovery Develop and execute downstream mechanistic assays to validate and advance targets Collaborate closely with disease area, human genetics, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a go-getter with these qualifications. Basic Qualifications: Doctorate degree PhD, PharmD, MD and relevant post-doc experience Or Master’s degree and 3 years of target discovery and biology experience Or Bachelor’s degree and 5 years of target discovery and biology experience Preferred Qualifications: Doctorate degree in epigenetics, genetics, chromatin biology, genomics, cell and molecular biology, developmental biology, systems biology, or related disciplines Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant contributions to discovery programs and publications in top tier journals Hands-on expertise conducting and delivering complex screening campaigns for discovery Proficiency with experimental design, data generation, and analysis principles across a broad range of technologies and assays including transcriptomics Experience with chromatin-focused methods such as ATAC-seq, ChIP-seq, Hi-C, CUT&RUN, CUT&Tag, or related approaches to study chromatin accessibility, genome architecture, and epigenetic regulation Strong expertise on prosecuting insights from human genetics along with approaches for in-depth biological study of potential targets Experience with programming (e.g. in R/Python), Unix/Linux environments, and cloud computing environments for the analysis of large omics datasets is preferred Strong written, verbal, and oral communication skills and ability to thrive in cross-functional settings What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen

Requirements

Doctorate degree PhD, PharmD, MD and relevant post-doc experience
Master’s degree and 3 years of target discovery and biology experience
Bachelor’s degree and 5 years of target discovery and biology experience

Nice To Haves

Doctorate degree in epigenetics, genetics, chromatin biology, genomics, cell and molecular biology, developmental biology, systems biology, or related disciplines
Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant contributions to discovery programs and publications in top tier journals
Hands-on expertise conducting and delivering complex screening campaigns for discovery
Proficiency with experimental design, data generation, and analysis principles across a broad range of technologies and assays including transcriptomics
Experience with chromatin-focused methods such as ATAC-seq, ChIP-seq, Hi-C, CUT&RUN, CUT&Tag, or related approaches to study chromatin accessibility, genome architecture, and epigenetic regulation
Strong expertise on prosecuting insights from human genetics along with approaches for in-depth biological study of potential targets
Experience with programming (e.g. in R/Python), Unix/Linux environments, and cloud computing environments for the analysis of large omics datasets is preferred
Strong written, verbal, and oral communication skills and ability to thrive in cross-functional settings

Responsibilities

Conduct impactful high throughput screening and profiling approaches for target discovery
Help identify and implement new technologies to accelerate discovery
Develop and execute downstream mechanistic assays to validate and advance targets
Collaborate closely with disease area, human genetics, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert
Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums