Senior Scientist – Research Computational Biology (ARIA)

Amgen • Thousand Oaks, CA

70d • $132,494 - $163,875

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate in computational biology, bioinformatics, data science, or a related discipline, or a Master’s degree with 3 years of relevant research experience, or a Bachelor’s degree with 5 years of relevant research experience.
• Strong programming skills (Python, R, Linux/Unix).
• Familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g., Git).
• Demonstrated expertise in the analysis and interpretation of single cell omics data.
• Excellent presentation and communication skills to convey complex findings to diverse audiences.
• Self-starter with a collaborative mentality and a drive for continuous growth.

Nice To Haves

• Strong background in cardiometabolic disease and/or immunology, including application to the interpretation of single-cell data.
• Experience leveraging and fine-tuning transcriptional foundation models, LLMs, and biomedical knowledge graphs.
• Familiarity with public data resources (e.g. DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M).
• Experience developing and deploying tools and pipelines to endpoints such as interactive portals (e.g. RShiny apps) and workflow management systems (e.g Nextflow).

Responsibilities

• Apply expertise in data science and disease biology to accelerate the identification, prioritization, and validation of transformative therapeutic targets.
• Extract biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms.
• Identify novel targets and biomarkers, and test therapeutic hypotheses.
• Develop and leverage methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities.
• Conduct innovative research in close partnership with Amgen therapeutic area scientists.
• Partner with data science and information systems teams to incorporate tools and analyses into integrated R&D platforms.

Benefits

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions.
• Group medical, dental and vision coverage.
• Life and disability insurance, and flexible spending accounts.
• Discretionary annual bonus program.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees