Senior Scientist, Product and Analytical Sciences, Cell Therapy Development Operation

Celgene • Warren, NJ

61d

About The Position

As part of the Product and Analytical Sciences group, the energetic and self-motivated Sr. Scientist will serve as both a functional program leader or technical lead and as an independent contributor bench scientist to achieve program, platform, and functional objectives. Where applicable, the incumbent may also serve as liaison between the Product Sciences sub-function and Clinical routine testing groups, CMC, Analytical Strategy, Informatics and/or Translational research teams as part of his/her work. Scientifically, the incumbent will lead/co-lead the design, execution and interpretation of complex experiments/studies related to the development of new/enhanced knowledge regarding CAR T cell products, intermediates, starting materials as it applies to the manufacturing process and clinical or manufacturing-related investigations within a CMC technical development function.

Requirements

• B.S. or M.S. in Immunology, Cell/Molecular Biology, Biomedical Sciences or related with 7+ years academic and/or industrial experience.
• At least 3 years of industry experience in a cell therapy matrix environment.
• Ph.D. in Immunology, Cell/Molecular Biology, Biomedical sciences, or related discipline with 5 years of academic and/or industrial experience , preferably in cell therapy development with proven history of productivity via scientific/technical abstract or article publications.
• Demonstrated leading potential from a functional programmatic level or a SME Technical Senior level.
• Experience with analytical method development for a variety of cell-based bioassays, binding assays and/or residual impurities assays are required.
• Advanced knowledge of basic techniques in immunology, cell biology and molecular biology is required.
• Experience in mammalian cell culture techniques, including isolation of immune cell subsets, maintenance and expansion of primary cells and cell lines is required.
• Presentation of data internally and across functions.
• High motivation and drive to acquire new skills and knowledge are desired.
• Willingness to work in a regulated industrial environment.

Nice To Haves

• Experience with FACS (A5, Lyric, Attune cytometers), immunofluorescence-based assays (Incucyte/Imagestream), Luminex, PCR and ddPCR, cytokine and chemokine detection (ELLA/MSD platforms), cell-based bioassays are highly desired.
• Powerful desire to work within a team structure and to develop, mentor and coach team members leading to their success, engagement and growth are required.
• Ability to work under minimal technical supervision, perform technical, strategic, and operational tasks independently and lead complex and cross-functional activities.
• Multiomics experience is desirable but not required.

Responsibilities

• Lead or co-lead technical development and execution of sensitive bioanalytical assays to characterize cell products, intermediates and starting material for internal and external collaborations and deliverables.
• Contribute to the development of biological hypotheses relating to product cellular attributes and their impact on clinical outcomes, manufacturing, and development of analytical tools.
• Develop and execute complex routine and exploratory characterization assays relating to clinical and manufacturing investigations.
• Contribute to informatics-based correlation studies supporting identification of critical product attributes.
• Support CMC objectives by providing biological and technical knowledge across program and platform strategies for product, process, and analytical development.
• Efficiently organize data and share findings within and across functional teams.
• Development of programmatic exploratory bench workstreams in the context of product biological understanding using multiomic technologies (e.g., nanostring, O-link, spectral cytometry, seahorse, etc.)
• Contribute to mentorship, support and empower the development of junior scientists as it relates to both technical and strategic elements of cell therapy product development.
• Ensure proper operation and perform routine maintenance of all laboratory equipment.
• Maintain a safe workplace in accordance with company and OSHA policies/procedures.

Benefits

• Medical, pharmacy, dental and vision care.
• Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
• Financial well-being resources and a 401(K).
• Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support.
• Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
• Parental, caregiver, bereavement, and military leave.
• Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources.
• Other perks like tuition reimbursement and a recognition program.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees