Senior Scientist/Principal Scientist, Quantitative Pharmacology

Legend Biotech • Franklin Township, NJ

94d

About The Position

Legend Biotech is seeking Senior Scientist/Principal Scientist, Quantitative Pharmacology as part of the Research & Early Development team based in Somerset, NJ. The position seeks a highly motivated and experienced quantitative pharmacologist to lead modeling and simulation efforts in support of gene and cell therapy products, with a focus on QSP and popPK modeling (Prior cell and gene therapy experience preferred).

Requirements

• MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline.
• 7+ years with MS degree or 3+ years with PhD/Pharm D degree of working experience in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CRO companies.
• Have strong execution ability.
• Strong independent scientific research ability, logical thinking, and coordination/problem-solving skills.
• Have clear written and oral communication skills.
• Have a good team spirit.
• Demonstrated expertise in QSP and popPK modeling, including proficiency with tools such as NONMEM, R, MATLAB, Monolix, etc.
• Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and model-informed drug development (MIDD) in clinical trials and drug development.
• Demonstrated ability and experience in applying modelling and simulation approaches to enable rational and efficient preclinical and clinical drug development.
• Familiar with regulatory requirements and guidelines of clinical pharmacology.
• Good project management skills, and the ability to collaborate with other departments and manage with internal and external partners.
• Proven track record of scientific contributions through publications or presentations.
• Good personality, honest and trustworthy.
• Physically and mentally healthy, love life.

Responsibilities

• Lead QSP and popPK modeling activities across preclinical and clinical development stages.
• Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD).
• Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability.
• Conduct simulations to support dose selection, trial design, and exposure-response analyses.
• Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams.
• Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs).
• Contribute to scientific publications and conference presentations.

Benefits

• Medical, dental, and vision insurance.
• 401(k)-retirement plan with company match that vests fully on day one.
• Equity and stock options available to employees in eligible roles.
• Eight weeks of paid parental leave after just three months of employment.
• Paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays.
• Flexible spending and health savings accounts.
• Life and AD&D insurance.
• Short- and long-term disability coverage.
• Legal assistance.
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.
• Commuter benefits.
• Family planning and care resources.
• Well-being initiatives.
• Peer-to-peer recognition programs.

What This Job Offers

• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree