Senior / Scientist, Nucleic Acid Delivery
About The Position
We’re hiring a (Senior) Scientist, Nucleic Acid Delivery to lead development of next-generation platforms for targeted delivery of nucleic acid-based therapeutics, including lipid nanoparticles and alternative gene delivery systems. The role will span developing novel chemistries, targeting strategies, and formulations; standing up high-throughput, automated screens; and building novel characterization methods that explain and predict performance. You’ll partner with chemistry, biology, automation/robotics, and AI teams and leverage both internal team and external CROs to turn design–build–test–learn into a closed loop that continuously improves therapeutics discovery, development, and delivery.
Requirements
- Ph.D. in Chemical/Biomedical Engineering, Chemistry, Pharmaceutical Sciences, BioChemistry, or related field (or M.S./B.S. with 5–8+ years relevant industry experience).
- Deep expertise in nucleic-acid therapeutics, targeted delivery platforms, and biophysical/bioanalytical assays.
- Experience building developing in vitro assays and integrating analytical instruments into automated or modular experimentation platforms.
- Experience designing multiplexed in-vivo screens.
- Experience engaging with external partners such as CROs in designing and shepherding in vivo studies, including mouse and NHPs.
- Strong working knowledge of automation/HTS and experimental design/statistics including design-of-experiments and Bayesian optimization.
- Proficiency in Python or other scripting languages for data analysis
- Clear, concise documentation and communication; bias toward hypothesis-driven, quantitative decision-making.
Nice To Haves
- Targeted nanoparticle experience (antibody/ligand decoration, linker chemistry) and affinity analytics (SPR/BLI).
- Familiarity with GMP considerations for nanoparticle manufacturing.
- Familiarity with mRNA chemistry (base/cap/poly(A) engineering) and how cargo design interacts with LNP performance.
- Experience with peptide barcoding for delivery characterization.
Responsibilities
- Design modality-spanning libraries of delivery systems (LNPs and alternatives), exploring novel chemistries, architectures, and targeting strategies (antibodies/VHHs/peptides/glycans; tunable linker chemistries).
- Implement state-of-the art and develop next-generation characterization methods to evaluate formulation and delivery performance. Establish in-vitro assays and collaborate with external partners to design and execute in-vivo studies.
- Closed-Loop Experimentation and Execution: partner closely with engineering and automation to design and exercise platforms for automated, high-throughput experimentation and data-rich workflows. Collaborate with AI team to run iterative experiments in real time, enabling fast optimization and discovery cycles.
- Collaborate, Lead & communicate: Work with chemists, material scientists, engineers, and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align milestones with internal/external collaborators, contribute to IP and publications, and present findings across the org.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
101-250 employees
