Senior Scientist, Nucleic Acid Chemistry

Flagship Pioneering•Cambridge, MA

About The Position

The Company FL99 is developing novel delivery technologies that will fundamentally redefine how genetic medicines can treat disease. We’re looking for future colleagues who are driven to solve incredibly hard problems in a collaborative, fast-paced environment. If that sounds like you, we’d love to consider your application. We are seeking an outstanding Senior Scientist, Nucleic Acid Chemistry (exact title flexible based on qualifications) to join us in ideating and building the next generation of Programmable Medicines. Our mission is to completely re-imagine nucleic acid therapeutics, casting aside long-standing dogma to pioneer integrated innovation at the cutting edge of both payload and delivery. This is a rare and unique opportunity to be one of the first employees of a biotech startup that combines an insurgent, swing-for-the-fences mindset with the backing, resources, and know-how of one of biotech’s leading VCs.

Requirements

PhD in Chemistry or Biochemistry with deep experience in nucleic acid chemistry (e.g., synthesizing and applying chemical probes of DNA, developing small molecules to profile RNA structure, or creating tools to study nucleic acid modifications)
Expertise in methods for analyzing and purifying compounds (NMR, HPLC, LC-MS, etc.)
Fluency in standard molecular biology methods for producing and assaying nucleic acids (PCR, IVT, gel and capillary electrophoresis, etc.)
Experience with organic synthesis of small molecules
Caring deeply about your work and your colleagues
Passion for challenging, fast-paced, ever-changing science
Superior attention to detail and execution of experiments, both personally and via CROs
Technical expert : Your background is in Chemistry or Biochemistry, and you have relevant experience in nucleic acid innovation, production, purification, and assay development.
Mission-driven scientist : You have an unquenchable spirit to build something new that will create huge impact for the world.
Relentless pioneer : You thrive in new and unknown territory - capable of charting comprehensive but actionable plans, executing rapidly and iteratively to make progress, and reliably delivering decisive readouts on time.
Team player : You flourish in collaborative work environments with other highly skilled individuals. You readily support your colleagues’ challenges & celebrate their victories.
Effective communicator : You not only understand the science but are capable of conveying technical information in a clear, concise, and decisive manner.

Responsibilities

Contribute to Nucleic Acid Chemistry innovation , aligned with the company’s core strategic goals.
Molecular design
Synthesis scheme optimization
Assay design
Plan and execute Nucleic Acid Chemistry experiments.
Preparation, purification, and validation of small molecules (NMR, LC/MS, HPLC, etc.)
Reactions of small molecules with nucleic acids, including purification and validation
CRO management for small molecule synthesis