Senior Scientist - Method Development-Biomarker LC-MS/MS

Frontage Lab • Exton, PA

90d

About The Position

The Senior method development scientist supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). The senior method development scientist will be a member of the method development team, the responsibility includes serving as subject matter expert when new proposal is received, reviewing the client request and evaluating the feasibility of the project, developing the method after the contract is signed, transferring the developed method to the validation team, and troubleshooting for challenging method.

Requirements

• Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Biology or related scientific discipline.
• 6-10 years of direct experience of bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma or CRO industry.
• Demonstrated experience in mass-spectrometry method development for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis etc.
• Demonstrated experience in small molecule and protein mass-spectrometry of quantitation of antibody drug-conjugates (ADC), including total Antibody, Conjugated payload, and free payload.
• Experience with Oligonucleotides and liposomal drug quantitation using LC-MS/MS is a plus.
• Proven ability to successfully work in a team environment. Excellent oral and written communication skills.
• Good knowledge and application of GLP with the ability to train technical personnel.
• Efficient time management.
• Strong troubleshooting and analytical skills.
• Detail oriented and meticulous.
• Ability to work independently under time constraints.

Responsibilities

• Develop method using LC-MS/MS platform for large molecules (Proteins, antibodies, ADC, Oligonucleotides, Liposomal drugs, biomarkers, etc) quantitation in biological matrices.
• Facilitate the method transfer from the Method development team with the method validation team.
• Communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.
• Ability to work on multiple projects at the same time.
• Research literature and external sources and identify new techniques and procedures that strengthen Frontage's capabilities.
• Maintain the proper level of regulatory compliance. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.
• Help with training and/or mentoring of junior scientific staff.
• Set-up, utilize, and maintain complex instrumentation Follow safety precautions.

Benefits

• Health and dental insurance
• 401(k) plan
• Disability insurance
• Life insurance

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 501-1,000 employees