Senior Scientist, Medicinal Chemistry

Calico Life Sciences•South San Francisco, CA

21d•$166,000 - $191,000•Onsite

About The Position

We are seeking a highly motivated Senior Scientist to join our Medicinal Chemistry team. This critical role involves addressing challenging disease targets through the application of a variety of small molecule strategies and therapeutic modalities, contributing directly to the discovery of new medicines across Calico's diverse therapeutic areas. The ideal candidate will expertly drive the design and synthesis of lead compounds, apply a comprehensive understanding of medicinal chemistry, actively contribute to the management of external collaborations, and champion practical, cutting-edge methods and synthetic tactics within Calico's discovery programs.

Requirements

Ph.D./postdoctoral experience in Organic or Medicinal Chemistry with 5+ years of progressive experience in a biotechnology or pharmaceutical environment
Extensive working knowledge and practical application of modern medicinal chemistry and drug discovery techniques (e.g., hit finding technologies, structure-based drug design (SBDD), computational chemistry, and advanced multi-parameter optimization of target and druglike attributes, physicochemical, and ADME properties)
Proven track record of success across all phases of small molecule drug discovery, from hit identification through lead optimization
Successfully managed CRO chemistry teams, resulting in sustained high-quality output and enhanced productivity that directly contributed to positive project outcomes
Prior experience as a chemistry team leader on a project from hit identification to preclinical nomination preferred
Expertise in complex molecule synthesis and methods development, including multi-step synthesis, purification, and spectroscopic analysis techniques
Demonstrated achievements in delivering novel molecules to development candidate nomination, both individually and as part of a team
Strong publication and patent record in medicinal chemistry
Proven ability to effectively lead and manage external medicinal chemistry and synthetic chemistry partners
Self-motivated, enthusiastic, and highly adaptable individual with the ability to quickly identify core project challenges and pivot strategies in a fast-paced environment
Excellent team player with a proven ability to collaborate effectively in a multidisciplinary environment
Commitment to excellence, meticulous record-keeping, and strong data organization skills
Exceptional oral communication and writing skills
Must be willing to work onsite 5 days a week

Nice To Haves

Experience with covalent inhibitors, targeted protein degradation and proximity inducing agents
Experience with various hit identification technologies, including fragment-based drug design (FBDD), DNA-encoded library (DEL), high-throughput screening (HTS), virtual ligand screening (VLS), and de novo drug design
Experience implementing or leveraging AI/ML tools for hit identification, lead optimization, retrosynthesis planning, or predictive ADME/Tox modeling
Familiarity with contemporary synthetic and analytical chemistry techniques and technologies including high through-put experimentation (HTE) methodologies

Responsibilities

Leverage expertise in organic and medicinal chemistry to design and synthesize novel small molecules, identifying potential drug candidates
Proactively monitor and interpret biological testing, ADME characterization, and hit-to-lead/lead optimization profiling data to propose and execute innovative strategies for improving key drug attributes in a multi-parameter optimization fashion and identifying new target molecules
Independently lead and collaborate with external synthetic teams, ensuring excellence, high productivity, and agile prioritization
Effectively tackle, evaluate, and communicate research findings and project progress to chemistry, cross-functional teams, and senior leadership, enabling informed go/no-go decisions
Author and contribute to patent applications, study reports, and scientific publications