Senior Scientist, LCMS Peptide Quantitation (Oncology)

Vir Biotechnology • San Francisco, CA

365d • $151,000 - $199,000

About The Position

Vir Biotechnology is looking for an enthusiastic Senior Scientist in LCMS Peptide Quantitation accountable for ensuring development and execution of discovery to preclinical peptide quantitative assays. You will be involved in strategic planning and development of assays featuring quantitative measurement of peptides both from in-vitro and in-vivo sources. These assays support discovery, development and pharmacokinetics of conditionally activated biologics including T cell engagers and cytokines. You will lead technical collaboration and planning with internal cross-functional teams and represent Vir as a subject matter expert in modern peptide quantitation methods using LCMS. This role is located in our San Francisco headquarters with an expectation of at least 4 days per week in office.

Requirements

• A minimum of a Bachelor's degree in a scientific discipline with 10+ years of work experience, Master's degree with 8+ years or Ph.D. with 5+ years of industry work experience.
• Experience with LC/MS-MS is required.
• Experience developing hybrid immuno-capture LC-MS methods.
• Experience and understanding with successful implementation of bioanalytical methods per current regulatory guidance and expectations is beneficial.
• Experience with transfer of assays internally and externally is beneficial.
• Experience working in a GMP or GLP environment is desirable.
• Self-motivated to carry out both new and routine tasks.
• Contribute to discovery and development by identifying opportunities and supporting continuous improvement.

Responsibilities

• Chromatography and mass spectrometry method development for peptide quantitation in support of discovery, development and pre-clinical studies (PK).
• Generation of workflows using Data Independent-analysis/SWATH; Parallel Reaction Monitoring (or MRMHR); Multiple Reaction Monitoring, as well as Data-dependent analyses for peptide quantitation: applying the optimal use-case for each workflow.
• Perform proteolytic digestion of proteins for LCMS analyses.
• Perform protein immunocapture/affinity purification from biological matrices such as plasma or serum.
• Perform sample cleanup and purification for LCMS.
• Work cross-functionally with members of other departments to complete tasks when required.
• Write development reports, SOPs, and contribute to writing of relevant sections in IND submissions to regulatory authorities.
• Manage externally facing interactions and occasionally acting as a subject matter expert for the outsourcing of in-house developed methods (sample analysis and method: transfer, development, and validation oversight).

Benefits

• health, dental, vision, life and disability insurance benefits
• non-accrual paid time off
• company shut down for holidays
• commuter benefits
• child care reimbursement
• education reimbursement
• 401K match
• lunch each day in the office

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Bachelor's degree
• Number of Employees: 501-1,000 employees