Senior Scientist– Innate Immunity & In Vitro Modeling

Pfizer•Pearl River, NY

3d•Onsite

About The Position

Why Patients Need You Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world. What You Will Achieve As a Senior Scientist in Viral Vaccines group, you will spearhead groundbreaking research dissecting the early innate immune mechanisms that shape vaccine efficacy and reactogenicity. By leveraging your innovative mind and deep expertise in immunology, you will lead projects to uncover novel immunological mechanisms driving vaccine efficacy, and investigate/develop new models to drive vaccine selection and understanding. Your work will directly contribute to the discovery of new vaccine targets and the optimization of immunogenic formulations, ultimately advancing our mission to deliver life-saving vaccines and improve global health outcomes.

Requirements

PhD in Immunology 0 to 4 years of scientific/technical experience OR Master’s degree and between 7 to 10 years of scientific/technical experience
Strong background in innate immunity
Track record of scientific excellence in immunology
Highly skilled with biomarker assay platforms such as immunoassays (ADCC, ADCP, ELISPOT, ELISA, Luminex, MSD).
Proficiency in multiparametric flow cytometry assays including immunophenotyping and immune based functional assays
Expertise in primary cell immune isolation, differentiation and characterization from murine tissues and human blood
Extensive experience in innate immune cell subsets isolation and characterization using multi-color flow cytometry
Knowledge of trained immunity and systems vaccinology
Experience with human organoid vaccine models
Ability to perform complex data analysis and team player with strong communication skills
Strong time management and organizational skills

Nice To Haves

Experience with adjuvant vaccine assay development
Experience with coding, including writing R and Python scripts
Solid background in vaccine research, innate immunology, infectious diseases or related fields, and a desire to continue in a laboratory-focused role

Responsibilities

Regularly contribute and influence at the project team level.
Design and execute experiments to profile innate immune responses to vaccine candidates, driving candidate selection and advancement.
Develop in vitro and ex vivo assays and models to validate biomarkers predictive of vaccine efficacy and reactogenicity.
Develop, optimize, and perform flow cytometry and multiplex cytokine assays to support preclinical studies, and evaluate new models.
Supervise junior colleagues in design and execution of experiments.
Identify, trouble-shoot, and optimize relevant assay systems, technologies, and readouts.
Conduct research that leads to publication in peer-reviewed journals and presentation of data at internal and external meetings.
Effectively collaborate with other members of Vaccine Research & Development and supporting partner lines.

Benefits

participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program
401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
paid vacation, holiday and personal days
paid caregiver/parental and medical leave
health benefits to include medical, prescription drug, dental and vision coverage

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