Senior Scientist, Immunology

Flagship Pioneering, Inc.•Cambridge, MA

56d

About The Position

We are seeking a highly motivated Senior Scientist of Immunology with expertise in T cell biology and in vivo CAR-T therapy development to join our therapeutic discovery team. The candidate will focus on strategic planning and hands-on benchwork using in vitro and ex vivo experimental approaches. This position requires scientific and technical expertise, and experience with pre-clinical disease models, scientific curiosity, and the desire to overcome scientific challenges and drive excellence. This individual will have the opportunity to be a major contributor to our lead program and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team.

Requirements

Ph.D. in Immunology or related field with 5+ years of relevant experience and 2+ years of industry experience. Title will be commensurate with experience
Deep expertise in flow cytometry, including panel design, instrument setup, and data analysis
Experience handing primary T cells, human PBMC, and associated assays to determine T cell function and phenotype
Experience with mouse models and ex vivo tissue processing and analyses. Experience in humanized mouse models and NHP ex vivo analyses is preferred
Experience with in in vivo CAR-T is strongly preferred
Experience with non-viral delivery technologies and nucleic acid modalities is preferred
Highly motivated to execute at the bench, exceptional organizational, problem-solving, communication, and collaboration skills

Responsibilities

Independently design and execute complex in vitro assays to evaluate CAR-T cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts
Independently design and execute in vivo studies, including mice and NHPs and conduct ex vivo analysis of immune cells. Interact with CROs or academic collaborators for in vivo study related activities
Develop, optimize and troubleshoot experimental protocols, and maintain accurate and timely electronic laboratory notebook records
Analyze, interpret and communicate experimental data at lab and project team meetings
Comfortable working both as an independent contributor and as part of a collaborative, multidisciplinary team of scientists