Senior Scientist II, Systems Immunology

AbbVie • Cambridge, MA

411d • $103,500 - $197,000

About The Position

The Senior Scientist position at AbbVie Immunology focuses on advancing research in autoimmune and chronic inflammatory diseases through innovative approaches in genomics and bioinformatics. The role involves leading projects that utilize high-throughput single-cell biology experiments and computational analysis to generate insights into disease mechanisms and therapeutic targets. The successful candidate will collaborate with multidisciplinary teams and contribute to scientific publications and presentations, playing a crucial role in translating complex biological data into actionable medical insights.

Requirements

• MD-PhD degree in Physiology, Molecular Biology, Biochemistry, or related field with typically 4+ years of experience.
• Proven experience in designing, optimizing and executing multi-omics characterization of functional experiments.
• Strong background in molecular biology techniques like flow cytometry, western blot, IHC, etc.
• Proficiency in bioinformatic pipelines for analyzing biological datasets, particularly single-cell RNA-seq and single-cell ATAC-seq.
• Excellent problem-solving skills, with a collaborative mindset enabling effective teamwork across interdisciplinary environments.
• Strong publication record demonstrating expertise in target ID using functional experiments and analysis of genomic and epigenomic datasets.

Nice To Haves

• Experience working with animal models for disease.
• Familiarity designing, executing and analyzing CRISPR perturbation experiments.
• Experience in building and optimizing computational pipelines for large-scale single-cell RNA-seq analysis.

Responsibilities

• Lead research projects focused on epigenomic and transcriptomic profiling using cutting-edge NGS technologies.
• Design and execute functional experiments to investigate cellular processes and mechanisms related to autoimmune diseases.
• Conduct bioinformatic analysis of single-cell RNA-seq and single-cell ATAC-seq data to identify and validate disease-specific targets.
• Curate and interpret clinical metadata to integrate with molecular and cellular datasets and enhance research outcomes.
• Collaborate with multidisciplinary teams to derive insights into immunological diseases and identify novel therapeutic targets specific to patient cohorts.
• Contribute to presentations at scientific conferences and publish findings in peer-reviewed journals.

Benefits

• Paid time off (vacation, holidays, sick)
• Medical/dental/vision insurance
• 401(k) plan
• Short-term incentive programs
• Long-term incentive programs

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree