Senior Scientist II/Principal Scientist, Bioprocess Development

Flagship Pioneering•Cambridge, MA

1d•Onsite

About The Position

THE ROLE We are seeking a Principal Scientist or Senior Scientist II to build and lead bioprocess development and microbial production for a high impact, novel biological platform. This role will focus primarily on fermentation process development, scale-up strategy, and production robustness, translating early-stage biological systems into scalable and manufacturable processes. The successful candidate will work at the interface of microbial engineering and bioprocess optimization, guiding both process development and targeted strain improvements that enable industrial production. This individual will serve as a technical leader within a multidisciplinary team and help establish foundational capabilities in microbial manufacturing as the company grows.

Requirements

PhD in biochemical engineering, microbiology, chemical engineering, or a related discipline
Scientist II: At least 8 years of professional experience, including 3+ years developing microbial fermentation processes in an industrial or translational setting
Principal Scientist: At least 12 years of professional experience, including 5+ years developing microbial fermentation processes in an industrial or translational setting
Demonstrated expertise in fermentation scale-up, optimizing parameters such as oxygen transfer, feeding regimes, media composition, etc.
Hands-on experience developing and optimizing microbial fermentation across scales (e.g., 250 mL bench reactors through 50 L pilot-scale systems)
Experience designing and executing fermentation experiments using systematic optimization approaches, such as DOE or structured process screening
Experience working with external partners (CROs, CMOs, or manufacturing facilities) to develop or transfer fermentation processes, including preparation of process documentation and technical oversight
Experience operating as a technical leader, either through mentoring scientists, guiding cross-functional collaborators, establishing technical best practices, or contributing to strategic scientific planning in an industry environment

Nice To Haves

Experience developing fed-batch fermentation processes across a range of industrial microbial hosts, including bacteria, yeast, and filamentous fungi
Experience optimizing high-cell-density microbial fermentations
Experience building fermentation or bioprocess development capabilities and facilities within a start-up environment
Experience improving production performance through close collaboration or co-ownership of targeted strain engineering activities

Responsibilities

Lead development and optimization of microbial fermentation processes from laboratory scale through pilot-scale production
Design scalable fermentation strategies including media development, feeding regimes, oxygen transfer optimization, and process control
Translate biological discoveries into robust production systems by improving yield, productivity, and process reproducibility
Establish experimental frameworks for systematic process improvement, including DOE-based optimization and fermentation analytics
Develop and execute scale-up strategies and support technology transfer to external CROs, CMOs, or manufacturing partners
Contribute to long-term manufacturing strategy and help build the company’s microbial production platform