Senior Scientist II, Neuroscience
About The Position
We are seeking a highly motivated and qualified individual to join our Discovery Biology Department as a Senior Scientist II and work as part of a team to drive success. The Senior Scientist II will support ongoing RNA-based drug discovery projects in Neuroscience therapeutic areas. The successful candidate will have experience in neuroscience drug discovery and a deep understanding of human neurobiological processes that drive CNS disease pathophysiology. The Senior Scientist II will employ a variety of in vivo, ex vivo, and in vitro techniques to advance oligonucleotide therapeutics for neurological indications.
Requirements
- Ph.D. in Neuroscience, Pharmacology, or related scientific discipline
- 4-6 years of relevant biotech or pharmaceutical industry experience in neuroscience drug discovery.
- 4+ years of industry experience as a project team lead
- Experience with qPCR, ELISA, MSD, Western blot, flow cytometry, stem-loop qPCR, fluorescence microscopy and image analysis
- Experience with in vitro and ex vivo assay development to support compound screening and mechanistic studies
- Experience with rodent stereotaxic surgery techniques as well as brain tissue processing, embedding, microtomy, fixation and immunohistochemistry.
- Broad knowledge of scientific experience with track record of scientific achievement demonstrated by peer-reviewed publications.
- Proficiency working with Microsoft Office Suite Products.
- Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
- Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.
- Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment.
- Strong technical awareness in various aspects of drug development, adherence to rigorous scientific methods, and commitment to the scientific process
Nice To Haves
- Proven track record of advancing drug discovery programs to key decision points
- Strong expertise in developing novel assays for compound screening or mechanistic studies
Responsibilities
- Support in vitro and ex vivo studies through developing novel assays and optimizing existing assays for compound screening
- Support in vivo studies by performing basic animal handling and specialized CNS techniques (e.g. intracerebroventricular and intrathecal injection) as well as tissue dissection and processing
- Implement multiple state-of-the-art techniques in molecular biology, biochemistry, and microscopy to determine drug distribution, efficacy, safety, and mechanism of action
- Contributes to the identification and validation of therapeutic targets for siRNA approaches and supporting existing pipeline programs
- Manage external CROs and oversee study execution
- Maintain updated and well-organized lab notebooks
- Other duties as assigned.
Benefits
- Equity-based compensation
- Performance-based bonuses
- 401(k) with Company Match
- Medical, Dental, Vision
- Flexible Spending Account
- Life Insurance
- Employee Assistance Program
- Employee Discounts
- Gym Membership
- Paid Vacation
- Paid Holidays
- Paid Sick, Jury Duty, Bereavement
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
1-10 employees
