Senior Scientist I-II, Analytical Chemistry

ADARx Pharmaceuticals•San Diego, CA

69d•Onsite

About The Position

We are seeking a highly motivated and qualified individual to join our Discovery Chemistry Department as a Senior Scientist I-II and work as part of a team to drive success. Ideal candidates will be self-motivated, independent, committed to the generation of high-quality data within a fast-paced and innovative research team. The Senior Scientist I-II will support ongoing RNA-based drug discovery projects in several therapeutic areas. This position is responsible for lead analytical development activities to support development, purification and characterization of our on-going oligonucleotide-based drug discovery. The preferred candidate will have demonstrated experience in analytical test method development and validation, ideally with an emphasis on HPLC / UPLC and LC-MS techniques.

Requirements

Ph.D. in Analytical Chemistry, or related scientific discipline
2-5 years of biotech/pharmaceutical industry experience analytical chemistry.
Strong background knowledge and hands-on experience in common analytical techniques and instrumentation for pharmaceutical analysis (i.e. HPLC/UPLC, LCMS etc).
Extensive experience with analytical method development and validation.
Extensive knowledge of LCMS for quantification and structure identification of small molecules, peptides, proteins, and/or oligonucleotides is required.
Hands-on experience in operating high resolution accurate mass spectrometers (ToF, FT-ICR, Orbitrap).
Working knowledge and hands-on experience with various analytical and purification techniques, especially RP-HPLC, LC-MS, SEC, IEX, SAX, HIC etc.
Maintain HPLC/LCMS instrumentation and independently troubleshoot instrument problems.
Superior laboratory skills and awareness of laboratory safety.
Broad knowledge of scientific experience with track record of scientific achievement demonstrated by peer-reviewed publications.
Proficiency working with Microsoft Office Suite Products.
Must be able to work independently with supervision as needed.
Strong problem-solving skills and a proactive attitude towards exploring new approaches.
Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.
Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment.

Nice To Haves

Specific experience with the analysis of oligonucleotides and proteins is a plus.
Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management teams are essential for this role.
A track-record of impacting drug discovery programs through driving projects to key decision points.
In-depth knowledge of modern organic synthetic methods, purification and analytical techniques as well as medicinal chemistry.

Responsibilities

Carry out assigned laboratory functions applying knowledge and skill in an accurate, timely manner.
Independently develop analytical and purification methods for large molecules such as oligonucleotides, novel oligonucleotide conjugates, peptides and antibodies.
Design and perform innovative experiments to support the development of novel modalities.
Manage and maintain equipment, reagents and dedicated laboratory environment needed to carry out assignments.
Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audience.
Collaborate with different teams including chemistry, conjugation and biology to develop approaches for challenging separations.
Establish and maintain excellent working relationships with critical collaborative partners throughout the company.
Maintain updated and well-organized lab notebooks.
Execute daily chemistry operations with an approach designed to minimize risks and hazard waste streams.
Maintain all appropriate corporate standards for lab safety and hazardous material management.
Other duties as assigned.