Senior Scientist I – Critical Reagents

B2S Life Sciences LLC•Franklin, IN

19d•Onsite

About The Position

We are seeking a highly skilled and motivated Senior Scientist specializing with Biochemistry/Chemistry background to join B2S Critical Reagents Team Umbrella. The ideal candidate will play a key role in diligent design, generation, and characterization of critical reagents directly to the advancement of large molecule bioanalytical pipelines. The Senior Scientist I – Critical Reagents is responsible for the generation, characterization, and lifecycle management of custom critical reagents to support the development of robust, regulated bioanalytical assays for large-molecule biotherapeutics. Critical reagents include well-characterized polyclonal and monoclonal antibodies, recombinant proteins, conjugated proteins and peptides, gene therapy vectors, oligonucleotides, and critical reagent kits. This position offers an exciting opportunity to lead and collaborate within a multidisciplinary scientific environment, contributing to innovation, assay robustness, and scientific excellence across the development lifecycle of large-molecule biotherapeutics.

Requirements

Ph.D. degree in biochemistry, chemistry or related discipline with related experience in biology/chemistry techniques is required.
M.S. degree in biochemistry, chemistry or a related discipline, 10+ years with related experience in biology/chemistry techniques is required.
Hands-on experience with protein purification methodologies using various chromatography techniques.
Proficiency in basic protein characterization techniques such as ELISA, SDS-PAGE, analytical chromatography techniques [E.g. SEC, NP/RP – HPLC, ion exchange methodologies]
Strong communication and collaboration skills, with the ability to work effectively with internal teams, external partners, and key stakeholders.
Demonstrated organizational skills with exceptional attention to detail and a high degree of precision.
Proven ability to thrive in a fast-paced, dynamic, and highly multitasking environment while consistently delivering against objectives.
Excellent critical-thinking, problem-solving, and analytical skills, with the capability to design, execute, and interpret complex experiments and datasets.
Ability to work independently, manage multiple priorities, and deliver high-quality results under tight timelines and deadlines.

Nice To Haves

Experience or familiarity with protein and peptide conjugation techniques, including site-specific and non-site-specific labeling approaches (e.g., NHS-ester, maleimide, and click-chemistry-based conjugations) for use in regulated bioanalytical assays.
BLI/SPR or capillary electrophoresis [CE-SDS, cIEF]; or familiarity with protein stability profiling techniques [DLS/SLS/ DSF etc].

Responsibilities

Serves as a Scientist/Principal Scientist for clients’ projects.
Performs a variety of protein conjugation chemistry, protein purification activities and downstream biochemical/bioanalytical and biophysical characterization methodologies.
Able to design, execute, trouble shoot experiments associated with critical reagents generation and /or characterization with minimum supervision.
Compiles scientific data (including analysis and technical writing) and able to present data in an intelligible format suitable for a professional audience.
Able to train junior level scientists.
Reports and treats data with prominent level of integrity and ethics.
Complies with application able regulations (GXP); maintains proper records in accordance with standard operating procedures (SOPs) and policies; independently designs and performs scientific experiments with a pre-defined goal including developing new methodologies, protocols, and/or test procedures that contribute to core group research goals and reflect expert knowledge.
Independently apply basic scientific principles, performs literature searches, attends scientific meetings, and keeps up to date on literature in the biotherapeutic bioanalysis field.
Maintains laboratory equipment, as needed.
Other duties as assigned