Senior Scientist I, Cell-free Protein Synthesis

Generate Biomedicines • Somerville, MA

40d

About The Position

Generate is seeking a highly creative and technologically curious Senior Scientist I in Cell-free Protein Synthesis to be part of the CFPS group in our prototyping lab. We believe innovations at the intersection of machine learning, computational protein design, and HTP experimentation will transform the ways that we bring new therapies to patients.
The Senior Scientist will contribute to efforts to expand our intrinsically scalable CFPS platform using synthetic biology, ML-guided optimization and strain engineering, with the aim of increasing throughput, and dramatically shortening design-build-test-learn cycles of our therapeutic candidates. They will work to 1) further integrate CFPS technology into our HTP and Cryo-EM workflows combining synthetic biology, structural biology, automation, and machine learning, 2) optimize and expand our CFPS workflows across modalities, and 3) work closely with our production scientists to design and implement productionized workflows.
The successful candidate has a proven track record of cross-disciplinary quantitative research, combining deep understanding of synthetic biology and high-throughput experimentation. Close collaboration with members from Generate’s Protein Science, Cryo-EM, Computational, and Machine Learning teams will be crucial to produce game-changing novel CFPS workflows. This is an opportunity to perform highly innovative technology development, while being a part of the collaborative and premier scientific environment in a well-funded biotech startup.

Requirements

• BSc/MSc with 10+ years or PhD+4 years of experience in a relevant science/engineering field (biophysics, biochemistry, physical chemistry, biological engineering, quantitative/synthetic biology, or related discipline).
• Demonstrated expertise in implementation, analysis, and optimization of Cell-Free Protein Synthesis systems.
• Demonstrated experience in laboratory automation and high-throughput experimental design.
• Highly motivated, proactive and enthusiastic team player demonstrating flexibility and a sense of urgency

Nice To Haves

• Deep subject matter expertise and experience with Cryo-EM is a plus
• Experience with data analysis in Python, Matlab, R or equivalent is a plus

Responsibilities

• Expand Generate’s efforts to integrate CFPS into our HTP screening and Cryo-EM workflows.
• Lead part of the team efforts to optimize CFPS workflows using both experimental tools (strain engineering, synthetic biology, automation, Cryo-EM) and theory (computational analysis, statistics, and ML-guided optimization).
• Work with production and analytics teams in the Protein Sciences department to optimize scaled-up workflows and implement characterization of CFPS-produced material.
• Generate bold, creative, unconventional ideas, and be a point person for intellectual property and patent writing.
• Strategic experiment planning, data interpretation, summarization, and presentation with minimum supervision are required
• Involvement in accelerating the discovery, engineering and characterization of novel biologics in the pipeline programs
• Mentor and train scientists throughout the company.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 251-500 employees