Conception-posted 2 months ago
Senior
Berkeley, CA
11-50 employees

Conception is pioneering the future of reproductive biology by generating functional human eggs from induced pluripotent stem cells (iPSCs). Our mission is to unlock new possibilities for fertility, reproductive health, and genetic diversity. We are building a world-class team to make this vision a reality. We are seeking an exceptionally smart and curious senior scientist to own the vision and execution of experiments to define how epigenetic state governs competence for germline specification and progression through meiosis I and II. You will independently drive exploration of histone modifications and DNA methylation profiles of our cells against in vivo references, and explore how epigenetic status impacts germline competence between species with the goal of understanding how we can improve our stem cell derived germ cells. This work will have a long term impact on egg and embryo quality.

  • Define the key questions and roadmap linking epigenetic signature to germline competence and meiotic progression.
  • Translate and execute experiments to address key questions.
  • Define an epigenetic scorecard to benchmark our cells against in vivo counterparts.
  • Make new pluripotent cell lines and benchmark them to interrogate the impact of somatic epigenetic memory.
  • Stabilize desired cell states by identifying and testing TFs and TF networks.
  • Collaborate with a computational biology scientist for cross-species comparisons of epigenetic profiles.
  • Drive experiments in collaboration with the cell engineering team to explore epigenetic perturbations.
  • Design and interpret assays of epigenetic state in collaboration with NGS/sequencing and computational biology teams.
  • PhD in epigenetics, developmental biology, genetics, stem cell biology or related field.
  • Related postdoctoral work or industry experience.
  • Strong publication record on the epigenetics of pluripotency or early development.
  • Hands-on human ES/iPSC culture experience; bonus for experience deriving iPSC or ES cell lines.
  • Deep expertise in histone modification and/or DNA methylation profiling and interpretation.
  • Strong fluency with TF-centric chromatin biology and ATAC-seq.
  • Demonstrated experience designing and interpreting datasets such as ChIP-seq, CUT&RUN, ATAC-seq.
  • Familiarity with interpreting single cell and multi-omic assays is a plus.
  • Working knowledge of X-chromosome dynamics and genomic imprinting in pluripotent and germline contexts.
  • Ability to collaborate deeply with computational biologists.
  • Impact: Define and accelerate one of Conception’s most critical programs, with the potential to transform human reproduction.
  • Ownership: Operate with autonomy inside a growing biotech company.
  • Mission-driven: Work alongside passionate scientists tackling one of the most exciting frontiers in biology.
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