Senior Scientist, Chemical Biology and Proteomics

Pfizer • Groton, CT

407d • $88,300 - $147,100

About The Position

As a Senior Scientist in the Chemical Biology and Proteomics group at Pfizer, you will play a crucial role in the discovery of small molecule and synthetically derived drugs. Your work will focus on leveraging mass spectrometry-based proteomics to enhance the understanding of molecular mechanisms and drive innovation in laboratory operations. This position requires a blend of scientific excellence, creativity, and collaboration with cross-functional teams to enable new projects and contribute to the development of important new medicines.

Requirements

• Doctorate level degree in mass spectrometry-based proteomics/biochemistry/chemistry or related field with experience in chemical biology/chemo-proteomics.
• Hands-on experiences with high-resolution LC-MS instruments (e.g., QE-HF, Tribrids, Exploris 480, TimsTOF) to ensure high-quality data.
• Experience with quantitative proteomics data analysis, including Proteome Discoverer, MaxQuant, Spectronaut, or equivalent analysis platforms is required.
• Exceptional documentation and communication skills.
• Self-motivated and highly effective in a team-based environment.
• Examples of peer-reviewed publications from scientific work to date.

Nice To Haves

• Post-doctoral experience is a plus.
• Some programming expertise is a plus.
• Experience in affinity-based MS and proximity labeling methodology preferred.
• Proficiency in protein biochemistry techniques (examples may include subcellular fractionation, western blot, in-gel fluorescence) is preferred.
• Familiarity with bio-orthogonal chemistry, site-selective protein modification, photo affinity cross-linking, activity-based protein profiling (ABPP) is a plus.

Responsibilities

• Leverage mass spectrometry-based proteomics techniques for model characterization and molecular mechanism of action elucidation.
• Develop innovative chemical biology methods, with an emphasis on quantitative protein mass spectrometry technologies.
• Enable new small molecule projects in the portfolio, through collaborations with disease area biologists and chemists.
• Present and report data with follow up discussions for project teams including data impact and interpretation.
• Enhance the external reputation of Pfizer's Chemical Biology and Proteomics capabilities through publications and presentations at leading conferences.
• Drive innovation in all aspects of laboratory operations including sample preparation, running and maintaining mass spectrometers, data analysis and interpretation.
• Work with local leadership to put in place an active program of self-development in proteomics and chemical biology skills.

Benefits

• 401(k) plan with Pfizer Matching Contributions
• Paid vacation, holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits including medical, prescription drug, dental and vision coverage
• Participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary
• Eligibility to participate in share-based long term incentive program
• Relocation assistance may be available based on business needs and/or eligibility.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree