Senior Scientist, Biologics Generation & Analytics

Takeda • Boston, MA

13d • $137,000 - $215,270

About The Position

The Research Senior Scientist is responsible for managing and performing scientific research, development, and testing of new products, manufacturing processes, and raw materials. This role aims to advance scientific knowledge and contribute to therapeutic advancements, aligning with Takeda's mission to deliver Better Health and a Brighter Future to people around the world.

Requirements

• In-depth experience with biologics and novel antibody designs.
• Experience with common cloning techniques such as Seamless, Gibson assembly or Golden Gate, PCR and plasmid DNA preparation are highly desirable
• Knowledge of high-throughput cloning and automation to assemble and generate DNA constructs to advance protein generation for multiple projects across many therapeutic areas.
• Extensive experience in molecular biology and reformatting protein/antibody workflows for expression and experience designing engineering solutions (multispecifics and innovative non-antibody fusions).
• Experience in intellectual property aspects as related to design and is experienced with bioinformatics approaches and algorithms that aid design.
• Expertise in different molecular biology databases at NCBI, Uniprot, etc., and multiple molecular biology software tools, such as Geneious Prime and Biologics, Genedata Biologics, and Snapgene
• Problem solver, capable of addressing and overcoming research challenges.
• Innovative thinker with a track record of applying new ideas to solve scientific problems.
• Excellent communication skills, adept at presenting complex data to diverse audiences.
• Committed to advancing scientific knowledge and contributing to therapeutic advancements.
• As an expert professional within the organization, you develop innovative solutions to complex problems aligned with organizational objectives. Your work involves addressing intricate issues, requiring in-depth analysis and judgment. You also engage with key contacts outside your expertise area and contribute to the development of new concepts and standards. Operating with considerable autonomy, you serve as a consultant to management and an external spokesperson on major matters, often working independently and leading function teams or projects. Additionally, you play a role in training and mentoring junior staff.

Nice To Haves

• Familiarity with cell line generation and CRISPR construct design in stable cell lines is nice to have

Responsibilities

• Independently design DNA constructs to be used for various therapeutic modalities, such as TCEs, mAbs, ADCs, and bispecifics, and be abreast with current scientific research
• Use demonstrated skills in molecular biology, plasmid design, and protein expression in mammalian cells to design DNA constructs for protein expression of antibodies, single domains, multispecifics, enzymes, membrane proteins, etc. in transient expression constructs or for lentiviral transduction or transposon technology in stable cell line generation
• Design and direct research strategy and activities to meet program goals; provide leadership, timelines and contingency plans
• Contribute to multiple projects, being a senior scientific consultant and guide the teams on which isoforms are relevant for target design
• Collaborate on Global Biologics project teams representing Biologics Generation and Analytics (BGA)
• Work collaboratively and effectively in a multi-disciplinary team environment as a team player, yet independently manage projects and lab work
• Multitask and work independently to meet aggressive timelines.
• Independently design, develop and execute research assignments and contribute to multiple projects, in parallel
• Develop the next generation of team members, act as an advocate for new opportunities for the team and members across functions

Benefits

• U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.
• U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: No Education Listed
• Number of Employees: 5,001-10,000 employees