Senior Scientist - Bioinformatics

Regeneron Pharmaceuticals•Tarrytown, GA

3d•Onsite

About The Position

The Molecular Profiling and Data Science Department is looking for an enthusiastic and motivated Computational Scientist who values independent research in an open and collaborative working environment. You will participate in original studies that span from basic research to translational studies, directly impacting the lives of patients. You will join a diverse and inspiring team which leverages bioinformatic strategies to optimize key aspects of gene therapeutic products, including expression, stability, splicing, and translation. You will work closely with the Regeneron Genetic Medicines Technology Center (RGM) to advance therapeutic development through cutting-edge computational support. You will utilize genomic and transcriptomic profiling sequencing tools to engineer delivery vehicles, evaluate therapeutic cargo efficacy, and identify the off-target effects of the delivered payload. In this role, a typical day might include the following: Lead computational on-target and off-target characterization of gene therapy programs, utilizing both empirical NGS datasets and in silico prediction models. Build and refine models to predict, score, and prioritize therapeutic off-target effects across the transcriptome and genome. Use computational approaches to optimize expression of therapy payloads (siRNA, shRNA, snRNA and microRNA) and delivery of viral and non-viral vehicle technologies. Develop internal tools, pipelines, workflows, and documentation that raise the analytical standards of the Molecular Profiling and Data Science group. Contribute with technical expertise on discussions of research efforts conducted by your and other departments in the company. Prepare and deliver clear, concise scientific presentations for collaborators and senior management. This job might be for you if you: Have a strong background in gene therapy and differential gene expression analysis. Have direct experience or is very familiar with the production of a range of NGS datasets. Bring innovative thinking to multi-omics data analysis. Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron. Can effectively communicate with collaborators of various scientific backgrounds. Value teamwork and team excellence. In order to be considered for this role, you must have: Ph.D. in Data Science, computational biology, or related field 0-2 years of relevant experience Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries’ specific benefits, please speak to your recruiter. Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $109,900.00 - $179,300.00 Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.

Requirements

Ph.D. in Data Science, computational biology, or related field
0-2 years of relevant experience
Have a strong background in gene therapy and differential gene expression analysis.
Have direct experience or is very familiar with the production of a range of NGS datasets.
Bring innovative thinking to multi-omics data analysis.
Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron.
Can effectively communicate with collaborators of various scientific backgrounds.
Value teamwork and team excellence.

Responsibilities

Lead computational on-target and off-target characterization of gene therapy programs, utilizing both empirical NGS datasets and in silico prediction models.
Build and refine models to predict, score, and prioritize therapeutic off-target effects across the transcriptome and genome.
Use computational approaches to optimize expression of therapy payloads (siRNA, shRNA, snRNA and microRNA) and delivery of viral and non-viral vehicle technologies.
Develop internal tools, pipelines, workflows, and documentation that raise the analytical standards of the Molecular Profiling and Data Science group.
Contribute with technical expertise on discussions of research efforts conducted by your and other departments in the company.
Prepare and deliver clear, concise scientific presentations for collaborators and senior management.

Benefits

health and wellness programs (including medical, dental, vision, life, and disability insurance)
fitness centers
401(k) company match
family support benefits
equity awards
annual bonuses
paid time off
paid leaves (e.g., military and parental leave)

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