Senior Scientist - Biocatalysis

Novo Nordisk • Boulder, CO

402d

About The Position

Novo Nordisk is seeking a Senior Scientist to lead process development for enzymatic ligation of oligonucleotides and biocatalytic processes related to RNA synthesis. This role involves scientific contributions to the development of enzymatic processes for manufacturing raw materials and API candidates, while collaborating with multi-disciplinary teams and managing research projects focused on sustainable oligonucleotide production.

Requirements

• PhD or MS degree in oligonucleotide chemistry, biochemistry, biocatalysis, enzymology, structural biology, or a related field.
• In-depth knowledge of nucleic acid/oligonucleotide chemistry and standard analytical methods.
• 6+ years of experience with oligonucleotides and/or biocatalysis in discovery, development, and scale-up of enzyme catalyzed reactions.
• Outstanding aptitude for experimental design, assay development, and problem solving.
• Familiarity with GMP and regulatory requirements in drug development.
• Strong communication and collaboration skills.

Nice To Haves

• Experience in a timeline-driven, dynamic environment.
• Ability to rapidly adapt to new techniques and protocols.

Responsibilities

• Lead and execute development projects directed at biocatalytic methods of oligonucleotide production.
• Serve as a subject matter expert in enzyme classes relevant to nucleic acid production, including enzyme screening and protein engineering.
• Direct internal and external research projects focusing on sustainable manufacturing of oligonucleotides.
• Contribute to the design of laboratory space for enzymology and biocatalysis research.
• Collaborate with teams at various locations and with CMOs/CROs.
• Compose technical reports, track sustainability metrics, and transfer methods to CMOs/CROs.

Benefits

• Medical, dental, and vision coverage
• Life insurance
• Disability insurance
• 401(k) savings plan
• Flexible spending accounts
• Employee assistance program
• Tuition reimbursement program
• Voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance, and auto/home insurance
• Sick time policy
• Flexible vacation policy
• Parental leave policy

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Merchant Wholesalers, Nondurable Goods
• Education Level: Master's degree