Senior Scientist, Antibody Discovery & Engineering

Pfizer•Bothell, WA

19d•Onsite

About The Position

As a research scientist, you will be part of Pfizer's Worldwide Research and Development team that employs a multidisciplinary approach to identify cancer targets and develop next generation Oncology therapeutics and therapeutic combinations. In this role, you will contribute to the development of novel biotherapeutics as a molecular biology subject matter expert. You will be responsible for extensive molecular biology design, experimentation, and analysis, including construct design, vector cloning, and NGS library preparation. You will also contribute to molecular analyses of cancer targets, cell line engineering, antibody sequencing, identification of sequence liabilities, and antibody engineering. With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide your team members. It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

Requirements

Ph.D. in Molecular Biology or related discipline or Bachelor’s degree + 9 years research experience or Master’s degree + 7 years research experience
Experience working with antibody sequences, including diversity analysis, liability identification, and CDR annotation
Molecular biology skills, including RNA/DNA extractions, primer design, PCR, plasmid cloning, and NGS library prep
Familiarity with sequence analysis software, such as Snapgene and/or Geneious Prime
Understanding of protein structure and biology; working knowledge of online bioinformatics tools to analyze gene, mRNA and protein sequences.
Demonstrated ability to work independently and collaboratively, adapting to project needs
Ability to organize and prioritize work to meet timelines and deliverables
Strong written and verbal communication skills, including ability to accurately document experiment data and present results

Nice To Haves

Proficiency in Oxford Nanopore sequencing and data analysis
Experience coding in Python, R, or other programming language
Understanding of antibody biology and antibody drug conjugates (ADCs)
Experience with cell engineering technologies, such as transfection, nucleofection, lentiviral transduction, and CRISPR
Proficiency in culturing multiple cell lines under BSL2 conditions
Exposure to working in the biopharmaceutical industry
Passion for identifying and implementing new technologies that improve workflow efficiency and deliverable quality

Responsibilities

Provide molecular biology and engineering support for multiple Oncology Research projects
Generate, analyze, and engineer antibody sequences to deliver an optimized therapeutic lead
Contribute to achievement of goals and influence at the project team level
Evaluate data and provide clear reports that can be shared and transferred to and from cross-functional teams
Pay attention to detail, strictly adhere to safety protocols, and use knowledge of basic laboratory procedures to advance projects under rapidly shifting priorities and timelines

Benefits

participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program
401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
paid vacation, holiday and personal days
paid caregiver/parental and medical leave
health benefits to include medical, prescription drug, dental and vision coverage

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