Senior Scientist, Analytical and Biological Mass Spectrometry

Regeneron Pharmaceuticals • Tarrytown, GA

1d • Onsite

About The Position

Regeneron Pharmaceutical's Analytical and Biological Mass Spectrometry Group (ABMS), located in Tarrytown, NY is seeking a highly motivated Sr. Scientist. In this role, you will work in an innovative mass spectrometry lab and develop LC-MS methods for characterizing biotherapeutic products to support all stages of drug development, from early-stage candidate selections to late-stage regulatory submissions. You will conduct and develop innovative technologies to support a diverse Regeneron's R&D pipeline. A Typical Day in This Role Looks Like: Design, execute, and clearly communicate analytical characterization of biotherapeutics, including monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities (adeno-associated virus, siRNA, etc.) to support drug development. Lead and execute characterization activities, with an emphasis on intact-mass LC-MS technique to elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications. Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges. Advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency. Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN). Author and review regulatory submission documents, including IND, comparability, and BLA reports, and contribute to manuscripts for peer-reviewed publications. Represent analytical development on project teams, provide subject matter expertise, and communicate results at internal and external meetings. This Role May Be for You If: You thrive in a fast-paced, collaborative environment and consistently deliver results with efficiency and ownership. You quickly learn new technologies, solve complex problems, and demonstrate strong passion for science and innovation. You are self-motivated and proactive, with the ability to prioritize effectively and drive work forward with minimal supervision.

Requirements

• MS (2+ years) or PhD degree (0-2+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
• Extensive experience with advanced mass spectrometers (Q Exactive Plus, Q Exactive UHMR, Q-TOF, etc.), liquid chromatography, and data processing software (Skyline, Protein Metrics, etc.) is desired.

Nice To Haves

• Experience with extended characterization of monoclonal antibodies by mass spectrometry to support product and process development is a plus.
• Experience with automated liquid-handling systems (e.g., Bravo, KingFisher) and with experimental design and data analysis (e.g., design of experiments, molecular modeling, graphing, and statistical analysis software such as JMP) is a plus.

Responsibilities

• Design, execute, and clearly communicate analytical characterization of biotherapeutics, including monoclonal and bispecific antibodies, Fc-fusion proteins, and other modalities (adeno-associated virus, siRNA, etc.) to support drug development.
• Lead and execute characterization activities, with an emphasis on intact-mass LC-MS technique to elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications.
• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to solve drug development challenges.
• Advance LC-MS characterization of biotherapeutics by developing innovative techniques that address evolving developmental needs and improve operational efficiency.
• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN).
• Author and review regulatory submission documents, including IND, comparability, and BLA reports, and contribute to manuscripts for peer-reviewed publications.
• Represent analytical development on project teams, provide subject matter expertise, and communicate results at internal and external meetings.

Benefits

• We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels!
• For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.
• For other countries’ specific benefits, please speak to your recruiter.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree