Senior Safety Scientist

Revolution Medicines•Redwood City, CA

6d•$158,000 - $198,000•Hybrid

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Senior Safety Scientist within Global Patient Safety Science is an individual contributor who provides safety science and pharmacovigilance support to all products across the RevMed portfolio, which includes early and late phase development activities. The individual will be responsible for safety oversight of clinical studies, review and authoring of clinical trial protocols, IBs, ICFs, and DSURs. Additional safety related activities will involve medical review of individual case safety reports (ICSRs), safety surveillance of assigned products and active member of cross-functional teams. The Senior Safety Scientist will develop and maintain an understanding of the safety profile of the assigned product(s).

Requirements

A relevant postgraduate qualification (e.g., MD, PharmD, PHD/MSc in a Life sciences discipline, or other post-graduate health professional qualifications).
3 or more years of drug development experience in the pharmaceutical or related industry with at least 1 year in drug safety.
Proven success in creating and sustaining strong relationships with internal and external business partners across an organization to create positive partnerships.
Broad understanding of the scientific aspects of safety, PV (including GVP, GCP), and clinical/patient risk management and safety operations
Demonstrated ability to lead and influence, with and without authority, in a fast-paced environment
Strong presentation skills, effective at summarizing and presenting the key considerations and decision points
Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high-energy environment.
Detail-oriented with ability prioritize tasks and function independently as appropriate.
Strong organizational skills and an ability to interpret, discuss, and report trial level data effectively and identify trends.
Excellent written and verbal communication skills.

Nice To Haves

Demonstrated experience in the oncology therapeutic area through clinical practice, drug development, or other relevant industry experience.
In-depth understanding of global pharmacovigilance regulations and guidelines, including GVP, FDA, and EMA requirements.
Proficiency with pharmacovigilance databases and tools such as Argus and MedDRA coding.
Proven track record in preparing and reviewing regulatory safety documents, including NDAs, DSURs, and risk management plans.
Collaborative team player with experience working across cross-functional and global teams, including partnerships with CROs.
Strong ability to analyze safety data trends and communicate insights effectively to diverse stakeholders.

Responsibilities

Proactive medical safety surveillance of ongoing clinical trials for identification and management of safety
Prepare and present safety data summaries to internal and external stakeholders.
Risk management activities include, but are not limited to medical review of ICSRs, routine review of safety data and pertinent scientific literature articles.
Acquire and contribute knowledge of relevant drug class and/or competitor safety issues.
Identify potential clinical safety issues, and recommend appropriate risk mitigation measures.
Involvement in preparation and maintenance of relevant sections of clinical trial protocols, IBs (including the reference safety information section), ICFs, DSURs, RMPs, CCDS, and labelling, as required.
Perform safety review of clinical protocols, Investigator's Brochure (IB), informed consent form (ICF) and other related documents to ensure alignment with the safety strategy and ensure the appropriateness of risk management strategies and risk communication.
Accountable for the safety components of study reports (i.e., CSRs), publications, aggregate reports, and other regulatory documents.
Conducts signal detection and evaluation activities for assigned products for the continuous benefit-risk evaluation throughout the product lifecycle, and contributes/leads preparation for escalation to safety governance committees .
Supports implementation of decisions from the signal evaluation process, including updates to core safety information, Investigator’s Brochure and other key safety documents and deliverables.
Contributes to input related to regulatory filings, New Drug Applications [NDAs], Biologics License Applications [BLAs]), and responses to safety queries from third parties, such as regulatory agencies.
Establish and maintain collaborative working relationships with all key stakeholders (study team members, CROs, investigators, study sites, vendors, committees, etc.).
Consistently comply with all governing laws, regulations, RevMed standard operating procedures (SOPs) and other guidelines.