Senior Safety Scientist

Revolution Medicines•Redwood City, CA

2d•Onsite

About The Position

Revolution Medicines is a late-stage clinical oncology company focused on developing novel targeted therapies for patients with RAS-addicted cancers, with a pipeline of RAS(ON) inhibitors in clinical development. The Senior Safety Scientist is an individual contributor within Global Patient Safety Science, providing safety science and pharmacovigilance support across the company's product portfolio, encompassing both early and late phase development activities. This role involves safety oversight of clinical studies, review and authoring of various clinical trial documents, medical review of individual case safety reports (ICSRs), safety surveillance, and active participation in cross-functional teams. The Senior Safety Scientist is expected to develop and maintain a deep understanding of the safety profile of assigned products.

Requirements

A relevant postgraduate qualification (e.g., MD, PharmD, PHD/MSc in a Life sciences discipline, or other post-graduate health professional qualifications).
3 or more years of drug development experience in the pharmaceutical or related industry with at least 1 year in drug safety.
Proven success in creating and sustaining strong relationships with internal and external business partners across an organization to create positive partnerships.
Broad understanding of the scientific aspects of safety, PV (including GVP, GCP), and clinical/patient risk management and safety operations.
Demonstrated ability to lead and influence, with and without authority, in a fast-paced environment.
Strong presentation skills, effective at summarizing and presenting the key considerations and decision points.
Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high-energy environment.
Detail-oriented with ability prioritize tasks and function independently as appropriate.
Strong organizational skills and an ability to interpret, discuss, and report trial level data effectively and identify trends.
Excellent written and verbal communication skills.

Responsibilities

Proactive medical safety surveillance of ongoing clinical trials for identification and management of safety
Prepare and present safety data summaries to internal and external stakeholders.
Risk management activities include, but are not limited to medical review of ICSRs, routine review of safety data and pertinent scientific literature articles.
Acquire and contribute knowledge of relevant drug class and/or competitor safety issues.
Identify potential clinical safety issues and recommend appropriate risk mitigation measures.
Involvement in preparation and maintenance of relevant sections of clinical trial protocols, IBs (including the reference safety information section), ICFs, DSURs, RMPs, CCDS, and labelling, as required.
Perform safety review of clinical protocols, Investigator's Brochure (IB), informed consent form (ICF) and other related documents to ensure alignment with the safety strategy and ensure the appropriateness of risk management strategies and risk communication.
Accountable for the safety components of study reports (i.e., CSRs), publications, aggregate reports, and other regulatory documents.
Conducts signal detection and evaluation activities for assigned products for the continuous benefit-risk evaluation throughout the product lifecycle and contributes/leads preparation for escalation to safety governance committees.
Supports implementation of decisions from the signal evaluation process, including updates to core safety information, Investigator’s Brochure and other key safety documents and deliverables.
Contributes to input related to regulatory filings, New Drug Applications [NDAs], Biologics License Applications [BLAs]), and responses to safety queries from third parties, such as regulatory agencies.
Establish and maintain collaborative working relationships with all key stakeholders (study team members, CROs, investigators, study sites, vendors, committees, etc.).
Consistently comply with all governing laws, regulations, RevMed standard operating procedures (SOPs) and other guidelines.