Senior Research Associate, Protein Sciences

Ampersand Biomedicines•Boston, MA

51d•$81,000 - $107,300

About The Position

Ampersand is currently seeking a highly motivated scientist with a background in protein sciences to contribute to the discovery and development of AND-Body™ Therapeutics. The role will focus on antibody engineering, protein production and purification, and biochemical and biophysical characterization to support biologic therapeutics development.

Requirements

B.S. or M.S. in Biology, Biochemistry, or a related scientific discipline.
Minimum of 2 years of relevant laboratory experience in an academic or industrial setting.
Experience in construct design, plasmid prep, and protein/nucleic acid sequence analysis.
Hands-on experience in protein expression and purification, including production in E. coli, mammalian, and/or cell-free systems.
Strong theoretical knowledge and hands-on experience in chromatography, including FPLC (ÄKTA) and HPLC using SEC, HIC, and IEX chromatography columns.
Practical experience with multiple biochemical and biophysical techniques, including SDS-PAGE, Western blotting, BLI, SPR, DSF, DSC, MS, AlphaLISA, and HTRF.
Ability to analyze and interpret complex datasets using statistical software (e.g. Excel, GraphPad Prism).
Excellent data record keeping and organization.
Strong written and verbal communication skills, with the ability to clearly interpret data and present results to project teams.

Nice To Haves

Experience with high-throughput protein production and characterization
Experience with membrane protein production and characterization
Knowledge of protein structure and structure-based analysis tools.
Publication record and experience with scientific conference posters and presentations
Industry experience as a Protein Sciences team member within a pharmaceutical or biotechnology company

Responsibilities

Support the research team in protein production and characterization across multiple research programs.
Perform protein and antibody production activities, including cell culture, transfection, and protein purification.
Execute protein and antibody biophysical characterization using techniques such as SDS-PAGE, aSEC, BLI, SPR, DSF, DSC, cIEF and other emerging tools.
Optimize critical parameters for binding assays, including AlphaLISA and HTRF.
Perform ELISA assays to measure serum antibody titers and functional biomarkers.
Collaborate with team leads on antibody campaign efforts to support antibody discovery programs.
Maintain clear, effective communication and strong collaboration with cross-functional colleagues.
Ensure high standards of data integrity and maintain accurate and well-documented research records in electronic laboratory notebook (ELN).