Senior Research Associate, Process Development

Epicrispr Biotechnologies • South San Francisco, CA

1d • $90,000 - $108,000

About The Position

Epicrispr Biotechnologies is seeking a highly motivated Senior Research Associate to join our Process Development team. This individual will contribute to the development and optimization of our in-house AAV platform, support preclinical vector supply, and play an active role in day-to-day lab operations. The ideal candidate is a hands-on experimentalist with strong experience in mammalian cell culture and viral vector production, who thrives in a fast-paced, collaborative startup environment. This role will support the development of scalable and robust processes to advance our gene regulation platform.

Requirements

• B.S. degree in Cell Biology, Biochemistry, Biology, or a related discipline with 4+ years of relevant industry experience (or M.S. with 2+ years)
• Hands-on experience with mammalian cell culture (adherent and suspension), aseptic technique, and transient transfection
• Demonstrated proficiency in benchtop bioreactor AAV production (inoculation through clarification)
• Familiarity with AAV or viral vector production
• Experience with analytical methods such as PCR/dPCR and flow cytometry
• Solid data analysis skills with ability to interpret complex results, communicate findings, and recommend next steps
• Exceptional attention to detail with proven excellence in experimental documentation
• Strong critical thinking and creative problem-solving skills
• Self-motivated, proactive and takes initiative when managing multiple priorities
• Collaborative team player who communicates openly and effectively within department and cross-functionally

Nice To Haves

• Familiarity with statistical design and analysis, including Design of Experiments (DoE), is preferred
• Prior experience in a startup environment is a plus

Responsibilities

• Execute upstream AAV production (2-5L) using transient transfection in suspension cell culture, supporting iterative process improvements
• Conduct studies to develop representative scale-down models for manufacturing processes
• Contribute to DoE studies (shake flasks) and process characterization experiments to evaluate and define critical process parameters (CPPs) and assess their impact on critical quality attributes (CQAs)
• Support upstream production campaigns to meet preclinical material demands on schedule and within quality expectations
• Assist in generating and analyzing data sets to support process development reports, tech transfer documents, and internal presentations
• Perform and analyze dPCR and flow cytometry experiments
• Maintain thorough, accurate, and timely documentation of experimental methods, data, and results
• Support general lab operations including equipment maintenance, reagent and consumable inventory management, vendor coordination, and sample tracking
• Collaborate cross-functionally with Research, Analytical Development, and Manufacturing teams

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level