Senior Research Associate - In Vitro Pharmacology: Molecular and Cell Biology
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About The Position
In your role as Senior Research Associate - In Vitro Pharmacology: Molecular and Cell Biology, you will be responsible for development of cell-based assays for emerging targets and functional screening of drug candidates to guide candidate design and selection. You will design and drive molecular biology and cell line engineering workflows to enable cell-based assay development for mode-of-action studies and compound screening in projects across the therapeutic portfolio and designed for diverse drug modalities. You will further contribute to early screening strategy and execution of experimental work across the full scope of In Vitro Pharmacology team's functions. Our team works with diverse modalities: peptides and proteins, and small molecules, as well as occasionally oligonucleotides, and their conjugates, and your work's aim will be to enable identification of lead candidates with desired in vitro potency, efficacy and selectivity. To achieve that, you will design, evaluate and develop and implement new in vitro assay techniques and protocols and recommend instrumentation and technologies to support and enhance In Vitro Pharmacology team's workflows and capabilities. You will display subject matter knowledge within molecular and cell biology in the context of in vitro pharmacology throughout early-stage drug discovery, with a general understanding of the role of other scientific disciplines in applied drug research. To achieve this, you will conduct relevant research of primary scientific literature, internal records, and other databases, as well as draw upon your internal and external scientific network to obtain knowledge, advice, and/or experimental protocols. You may receive general instructions on routine work and detailed instructions on new projects or assignments and be expected to follow standard practices and procedures, but you will be expected to set and achieve your own day-to-day operations that may impact broader team operations. You will be relied upon informing research activities timelines to meet project deliverables, including data generation, analyses, and reporting. As a member of various project teams, you will be responsible for driving projects as an individual contributor, you will participate and impact data-driven decisions making process regarding projects prioritisation and progression. You will be expected to develop, execute, and document experimental procedures and to ensure that data is interpreted, processed, and stored in line with FAIR data principles. You will be required to present ideas and data internally at various group and project team settings. Depending upon business need or circumstance, you may be required to mentor or be shadowed by other team members. You may also be called upon to provide input and training related to specific in vitro biology and pharmacology methods or technologies, and to develop, optimize, and draft experimental protocols and study reports. In your daily work, you will collaborate closely with scientists within the Chemical Biology department, colleagues across Greater Boston and global R&D sites. The working environment in Research & Early Development is dynamic and innovative and involves interactions with colleagues from research sites in Denmark, UK, and China, with an excellent opportunity to establish a strong scientific network.
