Senior Research Associate, Drug Product

Revolution Medicines•Redwood City, CA

10d•$106,000 - $126,000•Hybrid

About The Position

We have an opening for a full-time position as a Senior Research Associate position within the Drug Product function of our Pharmaceutical Development and Manufacturing (PDM) department. The position will be laboratory-based and responsible for preformulation studies, preclinical formulations development, and troubleshooting to support Revolution Medicines’ drug product development.

Requirements

BS with minimum 5 years or MS with minimum 3 years of the relevant laboratory experience in pre-formulation, formulation development, solid form screening, and analytical development.
Proficient in laboratory analytical techniques, specifically in HPLC, NMR, PXRD, PLM, DSC, TGA, DVS, and PSD measurements.
Experience in preclinical formulation screening and development to support in-house formulation preparations and management.
Good understanding of basic organic chemistry and analytical chemistry.
Excellent communication skills and a collaborative team player.
Highly organized with strong attention to detail and documentation skills.
Ability to multi-task and thrive in a fast-paced innovative environment.

Nice To Haves

BS and/or MS degree in pharmaceutical sciences, chemistry, and chemical engineering, or related discipline.
HPLC method development experience is preferred.

Responsibilities

Conduct solution and solid-state preformulation studies for RevMed research and development candidates (i.e. solubility, dissolution, excipient compatibility, stability studies, permeability and biopharmaceutics assessment, mechanical and processing properties).
Conduct solid form related activities of new chemical entities during preclinical assessment and throughout the clinical development phases (ie. solid form screening, co-crystal and salt screening, solid form identification, and solid-state characterization).
Support preclinical and (if needed) clinical formulation development.
Collaborate with Research team and prepare preclinical formulations in a timely manner.
Analyze formulations using suitable analytical methods to assess formulation stability, and dose analysis.
Maintain good laboratory notebook record (i.e. ELN) to document formulation preparation process, test results, and lab activities.
Help to maintain and manage lab activities, such as chemical inventories, calibrations, safety practices, new equipment acquisition, installation, and training.
Conduct lab activities for troubleshooting formulation and solid form related issues.
Write, revise, and update formulation protocols in a timely manner; support efforts to maintain and organize formulation protocols.
Provide support to research and PDM organizations for requests related to API and formulations.
Work closely with immediate supervisor on problems that may be of moderate complexity.