Senior Research Associate, DMPK

Protagonist Therapeutics • Newark, CA

48d • $110,000 - $120,000

About The Position

We are seeking a Senior Research Associate in the Drug Metabolism and Pharmacokinetic (DMPK) department. The qualified candidate will be a critical member of the group and work closely with our established team performing various in vitro metabolism assays, metabolite identification studies, and bioanalytical work to screen chemical entities for new drug candidates. This is an exceptional opportunity to work with a core discovery group within a successful biopharmaceutical company and bring drugs from ideas to the clinic.

Requirements

• Bachelor's degree in Biological Sciences, Chemistry, or related field with at least five years of hands-on, relevant DMPK lab experience working with a mass spectrometer (or master's degree in Biological Sciences, Chemistry with at least two years of experience)
• Experience performing metabolic stability, CYP inhibition, and metabolite ID studies in liver subcellular fractions, preparing and analyzing samples from biological matrices using a mass spectrometer (LC-MS/MS) as the primary analytical tool, and with sample preparation and bioanalysis of preclinical in vitro and in vivo ADME/PK studies
• Strong consideration will be given to candidates proficient in using and troubleshooting an LC-MS/MS (Sciex instrumentation is a plus)
• Demonstrated technical proficiency, scientific creativity, problem solving ability, and capable of independently planning and executing experiments while proactively seeking out senior personnel to discuss potential solutions to problems
• Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment
• Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges

Responsibilities

• Perform various in vitro metabolism studies to address specific DMPK questions in drug discovery
• Develop analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules and peptides
• Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department
• Influence discovery decisions and contribute significantly to corporate goals and project milestones
• Maintain a command of relevant scientific literature, research method sections of DMPK publications and evaluate implications for internal projects
• Assume responsibility for maintaining laboratory equipment, facilitate its use by other scientists, and maintain clear, detailed, and up-to-date experimental records
• Conduct other duties as assigned

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Professional, Scientific, and Technical Services
• Number of Employees: 101-250 employees