Senior Research Associate, CryoEM

Generate Biomedicines • Andover, MA

85d • $83,000 - $108,000

About The Position

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees. Generate Biomedicines is seeking a Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies.

Requirements

• Recombinant protein expression in E. coli and mammalian cell lines, protein purification (ÄKTA-based), and associated analytical techniques (aSEC, DSF, SDS-PAGE).
• Demonstrated ability to work independently with minimal guidance while contributing to a collaborative research environment.
• Excellent troubleshooting and attention to detail.

Nice To Haves

• Prior exposure to CryoEM workflows or microscope operation (e.g., SerialEM, Vitrobot, GP2).
• Hands-on experience with liquid handlers (Tecan, Hamilton).
• Experience running binding assays (e.g., Octet or Gator Bio).

Responsibilities

• Drive the advancement of experiments and technologies by performing protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
• Operate CryoEM microscopes and execute automated data collection workflows with minimal guidance.
• Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments.
• Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
• Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
• Document experimental data and report findings in internal databases.
• Contribute to process optimization and implementation of new protocols.

Benefits

• Annual bonus
• Equity compensation
• Competitive benefits package

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Bachelor's degree
• Number of Employees: 251-500 employees