TEMP Senior Research Associate/ Associate Scientist, Protein Sciences
About The Position
CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engaging bispecific antibodies (“TCBs”), and immune modulators such as cytokines and checkpoint inhibitors (“CPIs”). Learn more at www.cytomX.com . You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. You will be responsible for Quality Control (QC) analysis, lab inventory management and distribution of protein and DNA reagents for discovery and development programs, formulation of samples for in vivo studies, small scale transfections and purification of novel reagents, and aiding in protein purification and transfection projects as needed for the Protein Sciences department.
Requirements
- Experience with protein characterization assays such as concentration determination, endotoxin measurements, SDS-PAGE, CE-SDS, and/or analytical SEC.
- Experience with tissue culture and aseptic technique.
- A very solid understanding of the basics of DNA and proteins.
- Previous experience with preparing buffers and other reagents.
- Previous experience with DNA sequencing.
- Experience with Microsoft Suite, including Powerpoint, Excel, and Word.
- Strong organizational skills, even in fast-moving, dynamic environments.
- Good interpersonal, collaborative, and communication skills.
- Ability to be adaptable and resilient with a focus on problem-solving.
- At the associate scientist level, must have the ability to own the full purification workflow as well as method development.
Nice To Haves
- Expertise in operating the Tecan and AKTA systems.
- Experience with Electronic Lab Notebooks.
- Experience in protein purification.
- Experience with intact LC-MS.
Responsibilities
- Take ownership of and manage the inventory, storage, and distribution of protein reagents and DNA plasmids utilizing an automated system.
- Take ownership of the workflow for small scale transfection, production, and purification to assist Research and Development.
- Communicate clearly with other departments and individuals to help fulfill protein, DNA, and formulation requests.
- Support the in vivo studies by providing required therapeutic agents in appropriate dosing formulations utilizing aseptic technique.
- Conduct QC testing such as protein concentration, SDS-PAGE, endotoxin measurement, and aggregation as required.
- Manage and perform Quality Control testing of DNA plasmids for protein production.
- Assist in sample preparation and basic data analysis for LC-MS studies.
- Manage the shipment of samples to and from CROs.
- Support with large scale protein production and purification as required, including upkeep of cell lines.
- Maintain general laboratory upkeep and lab inventory supplies such as buffers, reagents, and other consumables.
- Follow all laboratory safety guidelines and practices while performing all the above tasks.
- Prepare presentations and present experimental data as requested.
- Assisting working with or assisting vendors with maintaining or PMing departmental equipment.
- Assisting in the coordination and implementation of a laboratory move from one location to another.
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What This Job Offers
Career Level
Mid Level
