Senior Research Associate/Associate Scientist, Preclinical Formulation Development

Flagship Pioneering•Cambridge, MA

14d•$81,000 - $126,500

About The Position

Expedition Medicines Inc., is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! The Formulation team is seeking a highly motivated, attentive and self-driven candidate to join our team and contribute to the development of discovery compounds as an Senior Research Associate/Associate Scientist . This successful candidate will join an energizing and collaborative research environment working as part of cross function drug discovery teams in providing a develop-ability assessment of innovative molecules.

Requirements

B.S. or M.S. in Chemistry, Biochemistry, Chemical Engineering, or a related discipline is required
Three years minimum of industry, government or equivalent experience in small molecules formulation or a related field
Hands-on experience with one or more of the following techniques: HPLC, UV-visible, DSC etc
Experience with data analysis using standard software platforms (Excel, Prism etc.)
Practical experience in developing and preparing preclinical formulations (small molecules)
Basic knowledge of physicochemical properties and their relationship to formulation development
Basic knowledge of pharmacokinetics (PK) and biopharmaceutics principles
The ability to manage multiple parallel activities and deliver results to agreed timelines
Ability to do bench work independently
Strong collaboration, problem-solving, and adaptability in fast-paced research environments
Excellent written, oral, and visual communication skills
Excellent time management skills

Responsibilities

Execute stage appropriate, fit-for-purpose preclinical formulations preparation (Solutions, suspensions, emulsions, nanoparticles, SEDDS etc.) for oral, and parenteral formulations on a small scale for small molecules
Author protocols describing preparation of formulations for use at internal and external formulation labs
Basic drug substance characterization by using techniques such as HPLC/UPLC, XRPD, DSC and PLM.
Assessment of the chemical and physical properties of small molecules, such as solubility, dissolution, particle size and chemical stability
Routine lab support such as buffer and mobile phase preparation, pH meter calibration, basic troubleshooting of lab equipment, and coordinating with external instrument and service vendors.
Shipping and receiving samples between internal and external sites
Summarize experimental results and presents at team meetings and department presentations
Author templated memos and reports with limited guidance
Maintain detailed lab notebooks and reports in compliance with GLP/GMP guidelines (as applicable)
Evaluate novel drug delivery systems (e.g., lipid-based, amorphous solid dispersions, spray dry etc.) for poorly soluble compounds
Support transition of formulations from discovery to clinical development (e.g., bridging studies)
Independently design and perform focused experiments that drive progress in cross-functional formulation initiatives