Senior Research Associate/Associate Scientist, Biochemistry

Flagship Pioneering•Cambridge, MA

7d•$81,000 - $126,500•Onsite

About The Position

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking a highly motivated Senior Research Associate or Associate Scientist to support the characterization of biomolecules within a rapidly evolving formulation discovery platform. This role will apply a variety of biophysical and biochemical techniques to evaluate how formulations influence biomolecular integrity, aggregation, and functional stability. They can expect to work closely with chemistry and machine-learning scientists to generate high-quality experimental data that inform formulation design and predictive modeling efforts. An ideal candidate will have a strong foundation in biochemistry, structural biology, or biopolymer engineering, along with hands-on experience operating analytical instrumentation used for biomolecular characterization.

Requirements

Bachelor’s or Master’s degree in Biochemistry, Structural Biology, Molecular Biology, Biophysics, Chemical Biology, or a related field
Bachelor’s degree and 5-8+ years of biotechnology industry experience
Master’s degree and 3-6+ years of biotechnology industry experience
Experience working with proteins or other biomolecules in vitro.
Strong experience operating circular dichroism (CD) spectroscopy instruments, dynamic light scattering (DLS) instrumentation, and UV-Vis spectroscopy.
Familiarity with SDS-PAGE and electrophoresis techniques.
Strong organizational skills, attention to detail, and ability to maintain rigorous experimental documentation.
Ability to work collaboratively in a fast-paced, interdisciplinary startup environment.

Nice To Haves

Background in computational structural biology or protein biophysics.
Experience working with cell culture or tissue culture
Experience with IR or FTIR spectroscopy
Experience with chromatography and mass spectrometry sample preparation
Familiarity with calorimetry and other physical chemistry techniques
Experience analyzing biomolecular stability, aggregation, or degradation in complex chemical environments
Exposure to formulation development in agriculture, nutrition, or industrial applications.
Exposure to high-throughput or screening workflows.

Responsibilities

Biomolecular characterization Conduct experiments to assess biomolecular stability and solubility in diverse formulation conditions.
Evaluate structural integrity and folding of cargo using circular dichroism (CD) spectroscopy and complementary biophysical methods.
Measure biomolecular interactions and stability using spectroscopy, dynamic light scattering, and electrophoretic techniques.
Prepare samples for varied external workflows to assess molecular integrity and degradation.
Experimental pipeline support Collaborate closely with formulation chemists to screen cargo-formulation interactions across diverse experimental conditions.
Generate high-quality experimental datasets to support internal modeling and data analysis pipelines.
Assist in maintaining and troubleshooting laboratory instrumentation Maintain organized laboratory records, analyze results, and communicate findings clearly to cross-functional teams.
Develop reproducible workflows and assist in development of standard operating procedures (SOP).
Support the scale-up and automation of experimental workflows as the platform evolves.