Senior Research Associate, Analytical Science & Technology

Century Therapeutics • Branchburg, NJ

3h

About The Position

Century Therapeutics is developing novel allogeneic living cell products for oncology, autoimmune and metabolic diseases that overcome the limitations of current cell therapies. Century’s genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic cancers, autoimmune indications and metabolic disorders such as Type I Diabetes. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of patient care. Century’s foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells or pancreatic Beta islet cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform distinguishes Century’s from other approaches that utilize non-renewable, donor-derived cells. Role: Century Therapeutics is seeking a Senior Research Associate who is self-motivated and results-oriented to support analytical method development for Century’s cellular therapy programs. The successful candidate will be expected to assist with developing and optimizing analytical methods, designing and performing validation studies, transferring and executing QC methods, and analyzing/interpreting data. This role requires extensive collaboration with internal and external teams. The successful candidate will need a strong scientific background, interpersonal skills, organizational skills, effective communication skills, and the ability to work collaboratively with other groups across organizations.

Requirements

• B.S. or M.S. degree in a relevant biological, biochemical, or biotechnology field with the following experience: o Senior Research Associate: 2-4 years (B.S.) or 0-2 years (M.S.) of relevant professional experience
• Knowledge of and experience in CAR-T cell therapy preferred.
• Strong scientific acumen with basic understanding of analytical method development principles.
• Experience with cell-based functional assays, flow cytometry, and PCR-based assays.
• Experience with cell culture (mammalian) and aseptic techniques.
• Experience with designing, executing and troubleshooting new protocols and assays preferred.
• Excellent written and verbal communication skills.
• Attention to detail and accuracy, ability to think critically, and work in a fast-paced setting to meet deadlines and prioritize across multiple projects/platforms.

Nice To Haves

• Knowledge of MACSQuant 16 (or equivalent), Vi-CELL BLU (or equivalent), MSD (or standard ELISA platform) is ideal but not required.

Responsibilities

• Develop, tech transfer, and validate methods to enable internal and/or external QC testing.
• Author and contribute to assay protocols, SOPs and technical reports detailing experimental work and summarizing results.
• Perform analytical testing (cell-based functional assays, flow cytometry, PCR-based assays, etc.) and document testing under cGMP in collaboration with QC.
• Analyze experimental and testing data and provide routine updates to project leaders and management.
• Assist in tracking and trending, troubleshooting activities and failure investigations for analytical methods.
• Collaborate with internal and external team members.
• Foster a collaborative and scientifically rigorous team culture.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level