Senior Program Manager, Integration and Strategic Outputs

Summit Therapeutics Sub•Palo Alto, CA

10d•$174,000 - $204,500

About The Position

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summits core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence. Summits team is inspired to touch and help change lives through Summits clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including: Non-small Cell Lung Cancer (NSCLC) HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI. HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC. HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC. Colorectal Cancer (CRC) HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy. Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than Chinas National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland. The Senior Program Manager, Integration & Strategic Outputs is a key member of Summits Program Management & Business Strategy organization, responsible for enabling high-quality execution, integration, and decision-ready outputs across the oncology pipeline. This role serves as a strategic integrator across cross-functional teams driving Summit-sponsored studies, and new indication initiatives ensuring that clinical development objectives, functional execution, and governance expectations are aligned through the lifecycle of the defined program. In addition, this role is responsible for initiative towards building and refining programs and indication level infrastructure that supports scalable, transparent, and adaptive clinical development corporate goals. This includes developing dashboards, standard templates, and processes that provide real-time visibility into study progress, risks, and dependencies, while enabling continuous improvement as the organization and pipeline evolve.

Requirements

Bachelors degree required (scientific, technical, or business discipline preferred).
8+ years of experience in biopharma, biotechnology, or CRO environments
Direct experience supporting oncology drug development in solid tumors within early development and pivotal programs
Demonstrated experience in program management, Clinical operations and strategic execution
Experience operating in matrixed, fast-growing organizations
Collaborative leader with the ability to influence without authority
Strategic thinking with strong execution discipline
Exceptional communication (written and verbal) and stakeholder management skills
Highly organized, outcomes-driven, and comfortable managing multiple priorities
Strong problem-solving, scenario framing, and decision-support capabilities
Strong proficiency in Smartsheets, MS Office and dashboarding tools
Solid understanding of clinical development operations
Ability to synthesize complex information into clear strategic insights and executive-level outputs

Nice To Haves

Masters degree preferred
PMP certification preferred

Responsibilities

Program Execution & Milestone Delivery Drive execution against program-level and corporate milestones, proactively identifying risks, interdependencies, and mitigation strategies.
Ensure alignment between functional execution, program strategy, and governance expectations, particularly for Summit-sponsored Phase 2/3 studies.
Lead and coordinate complex, cross-functional workstreams tied to corporate goals.
New Indication & Program-Led Workstreams Lead program management and facilitation of new indication workstreams to establish and refine study assumptions frameworks, decision gates, and key inputs/outputs required to support downstream execution and portfolio value maximization.
Ensure consistency, rigor, and decision quality across indication expansion activities, ISTs, cooperative group studies, and evidence-generation strategies.
Portfolio Planning & Transparency Develop, maintain, and evolve an integrated portfolio source of truth for ELT and senior leadership, providing visibility across timelines, milestones, risks, and strategic dependencies.
Own and continuously enhance ELT-level dashboards and reporting outputs, integrating cross-functional inputs across Clinical, Biomarkers, CMC, Regulatory, and Business Strategy.
Ensure portfolio data translates into actionable insights for resource planning, budget forecasting, clinical demand, and clinical supply planning.
Clinical Development Process and Infrastructure Development Design and implement scalable Product/Program level infrastructure, tools, and playbooks that support repeatable, high-quality execution across the portfolio.
Develop standardized templates and frameworks, and ensure all processes and tools are documented, governed, and embedded within the PMO library.
Cross-Functional Alliance & Integration Partner closely with Clinical Operations, Development, Biometrics, Regulatory, CMC, Legal, Quality, IT, and Commercial teams to ensure integrated execution and decision-making.
Support integration of external collaborations like ISTs, Co-op groups into portfolio plans, milestone tracking, and strategic outputs.
Ensure clinical development milestones, program dependencies, and portfolio priorities remain aligned and visible.
Scenario Planning & Decision Support Frame clear problem statements, integrate cross-functional perspectives, assess risks and tradeoffs, and support leadership alignment prior to execution changes.
Lead integrated scenario planning for programs to drive critical decisions impacting Summit-sponsored studies.
Executive Communication & Leadership Prepare clear, concise, and decision-ready updates for the Department Heads and ELT, highlighting progress, risks, tradeoffs, and opportunities.
Navigate ambiguity with confidence, providing structure, clarity, and momentum in complex environments.
Foster strong cross-functional partnerships and act as a trusted thought partner to functional and program leaders.
All other duties as assigned