Senior/Principal Scientist

Orna Therapeutics•Watertown, MA

About The Position

The candidate will be responsible for the development of in-vitro transcription (IVT) conditions and purification processes for circular-RNA-based therapeutics to support various programs. Optimize reactions, starting materials, and process conditions. Contribute to downstream process development for purification of circular-RNA. Develop circular-RNA analytics for purity determination and impurity profiling. Ability to Supervise and mentor junior team members. Cross-train team members in RNA synthesis and purification. Why Orna? At Orna Therapeutics, we’re more than just a workplace—we’re a community. We believe in fostering an environment where individuals can grow, thrive, and make a lasting impact on the future of healthcare. Join us as we revolutionize RNA therapeutics and make a difference in the lives of patients around the world. Equal Employment Opportunity Statement Individuals seeking employment at Orna Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Requirements

PhD in Molecular Biology, Biochemistry, or a related field with 5+ years of industry experience or master’s degree with 10+ years of specialized experience
Demonstrated success in the purification of circular RNA from IVT reactions, specifically utilizing chromatography and filtration techniques.
Deep theoretical knowledge and robust hands-on experience with RNA splicing mechanisms and ribozyme biochemistry
In-depth knowledge of nucleic acid/oligonucleotides chemistry and standard analytical methods of these molecules.
A comprehensive foundation in cell biology is essential for this role.
Proven track record of managing and mentoring high-performing, motivated technical teams.
Hands-on experience with AKTA purifier with solid knowledge of Unicorn software.
The applicant should have strong communication and collaboration skills, along with multiple examples of a strong technical background.
Experience with bacterial and mammalian cell culture.
Experience with analytical techniques like ELISA, CE, HPLC, LC-MS.

Responsibilities

Development of in-vitro transcription (IVT) conditions and purification processes for circular-RNA-based therapeutics
Optimize reactions, starting materials, and process conditions
Contribute to downstream process development for purification of circular-RNA
Develop circular-RNA analytics for purity determination and impurity profiling
Supervise and mentor junior team members
Cross-train team members in RNA synthesis and purification

Benefits

This position will be eligible for an annual target bonus percentage and equity based on job level, generous time off policies, and a comprehensive benefits package.

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