Merck KGaA Darmstadt Germany-posted about 1 year ago
Full-time • Senior
Rahway, NJ
Chemical Manufacturing

The Senior Principal Scientist in Upstream Biologics Process R&D at Merck is a leadership role focused on driving innovation and developing robust manufacturing processes for biotherapeutics. This position requires collaboration with various teams to design and implement upstream cell-culture processes, ensuring efficient and effective development of drug candidates. The role emphasizes scientific leadership, strategic initiative execution, and fostering a diverse and inclusive work environment.

  • Serve as a scientific leader to shape and drive innovation across the Biologics pipeline, strategy, and science.
  • Anticipate and solve scientific and technical challenges across projects and functional teams, in a fast-paced, multidisciplinary environment.
  • Lead the development of robust and scalable upstream processes for biologics in various stages of clinical development, as well as process characterization and regulatory filings for successful commercialization.
  • Improve upstream processes by increasing efficiency and cost-effectiveness through research and innovation, while evaluating technologies and industry best practices.
  • Collaborate with academia, industry, and vendors to facilitate the development and early adoption of novel process technologies.
  • Contribute to strategic initiatives; work with senior leaders to establish overall project strategy and guide teams in its execution.
  • Conceptualize, plan, and execute projects using effective organizational, prioritization, and problem-solving skills.
  • Stay updated on the scientific and regulatory landscape; contribute scientifically and build your reputation through conference participation.
  • Represent BPR&D as an upstream bioprocess expert/co-leader in internal and cross-functional project teams.
  • Supervise, coach, and develop talent within the functional area; guide career development; build strong, collaborative teams.
  • Champion compliance and safety while promoting a culture of diversity, equity, and inclusion.
  • Ph.D. with 10+ years, MS with 12+ years, or BS with 14+ years of industry experience in Chemical/Biochemical Engineering or a related field.
  • Strong fundamental knowledge and subject matter expertise in cell-culture process development for biologics, fed-batch cell culture, bioreactor scale-up and scale-down, as well as recent advances and challenges in the field.
  • Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of cell-culture process development.
  • Track record of accomplishments in upstream bioprocessing with a history of peer-reviewed publications and presentations.
  • Strong understanding of cell metabolism and biochemical pathways relevant to bioprocessing.
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